Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul

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Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul

Purpose To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.

Methods Two groups were formed in patients with keratoconus undergoing cross-linking ; Grup 1. (N=18). Epithelial abrasion (9mm) 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. UVA 3mw/cm2 at 365nm for 30 min Grup 2. (N=21). 0.1 % Riboflavin drops in dextrane every 3 minutes and hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes.

before epithelial abrasion, after epithelial abrasion and Central corneal thicknesses were measured by ultrasound pachimetry before epithelial abrasion, after epithelial abrasion and 30 minutes after beginning riboflavin installation

Before epithelial abrasion After epithelial abrasion P Grup 1 457.2 + 62.6 395±54,9 <0,001 Grup 2 449.7 + 62.6 389,4±44,2 0,009 After epithelial abrasion 30 minutes after riboflavin installation P Grup 1 395±54,9 360±44,4 <0,001 Grup 2 389,4±44,2 374,4±38,1 0,08 450 440 430 420 410 400 390 380 370 360 Group 1 Group 2 After epithelial abrasion 30 minutes after riboflavin

Conclusion Decrease of corneal thickness continues with epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC. HPMC Rb+Dextran H2O Rb+Dextran H2O