Spironolactone Does Not Prevent Acute Mountain Sickness: A Prospective, Double- Blind, Randomized, Placebo-Controlled Trial by SPACE Trial Group (Spironolactone.

Slides:

Advertisements

Similar presentations

Stacy M. Boore, MD, Dov Bock, MS Wilderness & Environmental Medicine

Advertisements

Managing Anaphylaxis in a Jungle Environment

Clinical Images Wilderness & Environmental Medicine

An Assessment of Coliform Bacteria in Water Sources Near Appalachian Trail Shelters Within the Great Smoky Mountains National Park Brian C. Reed, MD,

Intoxication With a Ramp (Allium tricocca) Mimicker

Jonathan Reisman, MD, Dinesh Deonarain, MD, Buddha Basnyat, MD

Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): Randomized, Controlled Trial of Ibuprofen Versus Placebo for Prevention of Altitude.

Frostbite in a Sherpa Wilderness & Environmental Medicine

Complications of Steroid Use on Mt Everest

Littered Cans—Death Trap of Snakes

Acute Injury Risk and Severity in Indoor Climbing—A Prospective Analysis of 515,337 Indoor Climbing Wall Visits in 5 Years Volker R. Schöffl, MD, PhD,

Ricky L. Langley Wilderness & Environmental Medicine

Climbing the Education Mountain: Designing the New Diploma in Mountain Medicine for the United Kingdom Kyle Pattinson, BM, FRCA, Sarah Matthews, BSc,

Efficient Breathing Circuit for Use at Altitude

Wilderness Communications

Geert A. Buijze, MD, PhD, Maria T. Hopman, MD, PhD

Initial Assessment of the Ability of Ivermectin to Kill Ixodes scapularis and Dermacentor variabilis Ticks Feeding on Humans Johnathan M. Sheele, MD,

Effective Tick Removal With a Fishing Line Knot

Colin Powell, BSc (tech) FHEA Wilderness & Environmental Medicine

Prospective, Double-Blind, Randomized, Placebo-Controlled Comparison of Acetazolamide Versus Ibuprofen for Prophylaxis Against High Altitude Headache:

Migraine Headache Confounding the Diagnosis of Acute Mountain Sickness

Prospective, Double-Blind, Randomized, Placebo-Controlled Comparison of Acetazolamide Versus Ibuprofen for Prophylaxis Against High Altitude Headache:

Bruno Ernst Durrer, MD: January 14, 1953 to December 5, 2016

The Snow Snorkel: A Proof of Concept Study

Mountain Clothing and Thermoregulation: A Look Back

Prevention of Acute Mountain Sickness by Acetazolamide in Nepali Porters: A Double- Blind Controlled Trial Peter Hillenbrand, MB, Anil K. Pahari, MD,

Gordon G. Giesbrecht, PhD Wilderness & Environmental Medicine

Symptoms and Treatment of Acute Conjunctivitis Caused by Skin Secretions of Veined Tree Frog (Trachycephalus Venulosus) Levente Tanacs, MD, Etienne Littlefair,

Fernando A. Moraga, BSc, Jorge D. Osorio, BSc, Manuel E. Vargas, MD

Risk Determinants of Acute Mountain Sickness and Summit Success on a 6-Day Ascent of Mount Kilimanjaro (5895 m) James S. Lawrence, BMedSci, BMBS, Stephen.

The “Newbie” Syndrome Wilderness & Environmental Medicine

Migraine Headache Confounding the Diagnosis of Acute Mountain Sickness

Prophylactic Acetaminophen or Ibuprofen Result in Equivalent Acute Mountain Sickness Incidence at High Altitude: A Prospective Randomized Trial Nicholas.

A Pain in the Neck Wilderness & Environmental Medicine

Two Cases of Acute Kidney Injury Due to Multiple Wasp Stings

Background Rates of Acute Mountain Sickness-Like Symptoms at Low Altitude in Adolescents Using Lake Louise Score Jon Dallimore, MB, BS, MSc, MRCGP, MCEM,

Daniel A. Lack, PhD, Alison L. Sheets, MD, Jacob M. Entin, BA, David C

Pott’s Disease Resulting in Complete Cervical Vertebral Destruction

Forrest C. Wells, BS, Craig R. Warden, MD, MPH, MS

Samson Phan, MS, John Lissoway, MD, Grant S. Lipman, MD

Symptomatic Hypotonic Hyponatremia Presenting at High Altitude

Conduit Vessel Blood Flow During the Trek to Mount Everest Base Camp

Tribute to Jonna Barry Wilderness & Environmental Medicine

Gordon H. Worley, MSN, RN, FNP, EMT-P

M. Josephine Hessert, DO, MPH, Brad L. Bennett, PhD, MA, EMT-P

Diabetic Ketoacidosis and Acute Mountain Sickness: Case Report and Review of Treatment Options in Type 1 Diabetes Mellitus Steven C.M. Miller, BSc, MBChB,

Optic Nerve Sheath Diameter and Acute Mountain Sickness

Nikica Šprem, PhD, Petar Škavić, MD, Ivan Krupec, Ivica Budor, MS

Emmanuel Cauchy, MD, Christopher B

Subtle Cognitive Dysfunction in Resolving High Altitude Cerebral Edema Revealed by a Clock Drawing Test Ian Quigley, MBBS, Ken Zafren, MD Wilderness.

Sailing Injury and Illness: Results of an Online Survey

Henry R. Guly, FRCP, FCEM Wilderness & Environmental Medicine

Gregory D. Richardson, MD, Susanne J. Spano, MD

Wilderness First Aid Training

Frostbite in a Sherpa Wilderness & Environmental Medicine

Douglas McGraw, Stephen J. Gluckman, MD

Palsy in the Desert Wilderness & Environmental Medicine

A Broken Leg in the Bugs Wilderness & Environmental Medicine

Dr. Emmanuel Cauchy (1960−2018)—Reflections from Around the World

The Epidemiology of Caving Injuries in the United States

Management of High Altitude Pulmonary Edema in the Himalaya: A Review of 56 Cases Presenting at Pheriche Medical Aid Post (4240 m) Barbara E. Jones,

An Itchy Situation Wilderness & Environmental Medicine

Wolf Spider Envenomation

Acute Mountain Sickness (AMS) Knowledge Among High Altitude Marathon Runners Competing in the Everest Marathon Abigail Letchford, MBChB, Rudra Paudel,

Gordon G. Giesbrecht, PhD Wilderness & Environmental Medicine

Health of High Altitude Pilgrims: A Neglected Topic

Health of High Altitude Pilgrims: A Neglected Topic

Acute Mountain Sickness in Children at 4380 Meters in the Himalayas

Comparing Student Outcomes of Hybrid and Conventional Wilderness Emergency Medical Technician Programs Joshua D. Martin, DNP, WEMT-P Wilderness & Environmental.

Morteza Khodaee, MD, MPH, Jill Tirabassi, MD

Presentation transcript:

Spironolactone Does Not Prevent Acute Mountain Sickness: A Prospective, Double- Blind, Randomized, Placebo-Controlled Trial by SPACE Trial Group (Spironolactone and Acetazolamide Trial in the Prevention of Acute Mountain Sickness Group) Buddha Basnyat, MD, MSc, FACP, FRCP (E), Peter S. Holck, PhD, Matiram Pun, MBBS, Stephen Halverson, MD, Piotr Szawarski, MD, Jeffrey Gertsch, MD, Mike Steif, EMT, Skip Powell, MD, Subhash Khanal, MBBS, Anip Joshi, MBBS, Ravi Shankar, Jamie Karambay, MS, Hattie D. Alexander, MD, Allyson Stone, MS, Candice Morrissey, MSPH, Beth H. Thompson, MD, Jeremy Farrar, BSc, MBBS, FRCP, DPhil, OBE Wilderness & Environmental Medicine Volume 22, Issue 1, Pages 15-22 (March 2011) DOI: 10.1016/j.wem.2010.10.009 Copyright © 2011 Wilderness Medical Society Terms and Conditions

Figure 1 Lobuje: study endpoint. Wilderness & Environmental Medicine 2011 22, 15-22DOI: (10.1016/j.wem.2010.10.009) Copyright © 2011 Wilderness Medical Society Terms and Conditions

Figure 2 Study flow chart. Wilderness & Environmental Medicine 2011 22, 15-22DOI: (10.1016/j.wem.2010.10.009) Copyright © 2011 Wilderness Medical Society Terms and Conditions