The incidence of heparin-induced antibodies in patients undergoing vascular surgery: A prospective study Mark R. Jackson, MD, David L. Gillespie, MD,

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Presentation transcript:

The incidence of heparin-induced antibodies in patients undergoing vascular surgery: A prospective study Mark R. Jackson, MD, David L. Gillespie, MD, Audrey S. Chang, PhD, Elizabeth G. Longenecker, BS, RN, Raquel A. Peat, Barbara M. Alving, MD Journal of Vascular Surgery Volume 28, Issue 3, Pages 439-445 (September 1998) DOI: 10.1016/S0741-5214(98)70129-6 Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Schematic illustration of heparin/PF4 ELISA. Heparin-induced IgG antibodies from patient plasma bind the complex of heparin and PF4 in ELISA microtiter plate. Heparin-induced IgG antibodies (if present) are detected after incubation with alkaline phosphatase-labeled goat anti-human IgG and color development with enzyme substrate. Journal of Vascular Surgery 1998 28, 439-445DOI: (10.1016/S0741-5214(98)70129-6) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Box plots of quantitative ELISA results before and after vascular surgery. Groups are separately analyzed based on prior heparin exposure. Box plots depict the 25th to 75th percentiles for ODR values within the box. The horizontal line within the box is the median value. Extreme values are depicted by arrow bars. Journal of Vascular Surgery 1998 28, 439-445DOI: (10.1016/S0741-5214(98)70129-6) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Scatter plot of change in ODR (postoperative ODR minus baseline ODR) as a function of intraoperative heparin dose. The middle line is the linear regression line for mean values. Upper and lower lines represent the range of the 95% confidence interval. Journal of Vascular Surgery 1998 28, 439-445DOI: (10.1016/S0741-5214(98)70129-6) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions