Fig. 8. In vivo suppression of MM by CMLD

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Fig. 8. In vivo suppression of MM by CMLD010509. In vivo suppression of MM by CMLD010509. (A) Diagram of in vivo studies performed. SCID mice were injected with MM1S GFP (green fluorescent protein)/Luc+. After engraftment, the mice were randomized to two groups based on BLI, and CMLD010509 or vehicle control was administered by intraperitoneal (i.p.) injections at 0.7 mg/kg two times a week. Tumor growth was assessed by weekly bioluminescence (BLI) counts, (B) showing a significant difference in tumor growth between the DMSO-treated group and the CMLD010509 group; P < 0.001. (C) Kaplan-Meier curve showing a significant survival difference between vehicle- and drug-treated mice, with a median OS of 35 versus 47 days, P < 0.001. (D) Immunohistochemistry for CD138, Ki-67, and MYC in bone marrow samples from the KMS-11–injected mice. Scale bars, 50 μm. (E) Electrophoresis of serum proteins from transplantable Vk*Myc mice indicating the presence of a γ-globulin (M-spike) in the DMSO control group (arrow) at 4 weeks. C57BL/6 syngeneic mice were intravenously injected with 3.5 × 106 Vk*Myc cells. At day 7 after tumor cells injection, mice were randomized into two groups and received DMSO (n = 10) or CMLD010509 drug (n = 10, 0.7 mg/kg per mouse) through intraperitoneal injections twice a week. (F) Kaplan-Meier curve showing a significant survival difference between vehicle- and drug-treated mice, with a median OS of 39 days versus not reached, P = 0.0019. Statistical analyses were performed using log-rank test. Salomon Manier et al., Sci Transl Med 2017;9:eaal2668 Published by AAAS