Epithelial Homeostasis: A Piezo of the Puzzle Eugenia Piddini  Current Biology  Volume 27, Issue 6, Pages R232-R234 (March 2017) DOI: 10.1016/j.cub.2017.02.002 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Piezo1 mediates stretch-induced proliferation. Epithelial cell stretching induces opening of the stretch-activated calcium channel Piezo1. Calcium influx activates the calcium-sensitive kinase ERK1, which in turn causes cells that were in the G2 phase of the cell cycle to enter mitosis. Through this mechanism, epithelia react to stretching with a quick burst of cell divisions that counters the decrease in cell density. Current Biology 2017 27, R232-R234DOI: (10.1016/j.cub.2017.02.002) Copyright © 2017 Elsevier Ltd Terms and Conditions