Fig. 3. BET inhibition reduces homologous recombination.

Slides:

Advertisements

Similar presentations

Volume 21, Issue 12, Pages (December 2017)

Advertisements

Fig. 1. TP is highly expressed in myeloma.

Fig. 4. PVSRIPO infection of DCs is sublethal, is marginally productive, and induces sustained proinflammatory cytokine production. PVSRIPO infection of.

Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures.

Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

BET inhibition and depletion repress the expression of BRCA1 and RAD51

Fig. 2. Pharmacologic inhibition of ALK impairs STING activation.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 3. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis and survival. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis.

Fig. 4. aPD-1 mAb transfer to macrophages is mediated by FcγRs.

Fig. 1. Schematic representation of the MANO method.

JQ1 directly represses the promoter activities of BRCA1 and RAD51

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Fig. 1. PARPi and MEKi induce inverse adaptive responses.

Fig. 8. In vivo suppression of MM by CMLD

Fig. 3. A circadian rhythm in fibroblast wound-healing response.

Fig. 6. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific CTL immunity in vitro. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific.

Fig. 6. Effects of CD31-NP targeting in perfused human kidneys.

Volume 22, Issue 2, Pages (January 2018)

Fig. 5. Vascularization of human liver seed grafts.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Fig. 5. Remnants of PS+ platelets induce neutrophil macroaggregation.

Expression of SYCE2 activates the DSB repair pathway.

Fig. 6. Epitope mapping of C12G6.

Fig. 2 In vitro assessment of hESC-RPE cell sheets.

Fig. 2 STED microscopy of isolated cardiomyocytes from mice treated with MP-rhodamine–loaded CaPs. STED microscopy of isolated cardiomyocytes from mice.

Fig. 1. Muscles of LAMA2 MD patients and dyW/dyW mice contain high amounts of laminin-α4 and show deficits in BM. Muscles of LAMA2 MD patients and dyW/dyW.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Coupling of Homologous Recombination and the Checkpoint by ATR

Antiproliferative effects of JQ-EZ-05 on VHL−/− ccRCC are on-target

Fig. 1. Drug combination screen identifies BETi as acting synergistically with PARPi. Drug combination screen identifies BETi as acting synergistically.

Fig. 2. Binding of recombinant full-length Lm-411 to muscle receptors, myotubes, and self-polymerization is enhanced by mag and αLNNd. Binding of recombinant.

Fig. 5 Local gel scaffold for T cell memory response.

Fig. 2 Fas controls IL-1RA–sEV secretion in murine MSCs.

Fig. 1. PGBD5-expressing cells do not tolerate deficiency of nonhomologous end-joining DNA repair. PGBD5-expressing cells do not tolerate deficiency of.

Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Knockdown of DAO inhibits DNA damage–induced senescence.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

Fig. 7 DMN-Tre labeling of Mycobacterium tuberculosis is inhibited by tuberculosis drug cocktail, unlike auramine staining. DMN-Tre labeling of Mycobacterium.

Pharmacological inhibition of DAO impairs DNA damage– and oncogene-induced senescence. Pharmacological inhibition of DAO impairs DNA damage– and oncogene-induced.

Fig. 2 ALRN-6924 rapidly increases transcription at the p21 locus and affects its bursting dynamics. ALRN-6924 rapidly increases transcription at the p21.

Fig. 3. HECTD2 contains a naturally occurring polymorphism at A19, which mislocalizes to the cytosol. HECTD2 contains a naturally occurring polymorphism.

Bexarotene is neuroprotective in mouse and human HD neurons in vitro

Fig. 3 CSF1 is expressed in human melanoma.

Fig. 7 Analysis of the bacterial nidus within tissue abscesses by MALDI IMS demonstrates a paucity of calprotectin signal. Analysis of the bacterial nidus.

Volume 54, Issue 6, Pages (June 2014)

Fig. 5 BRD0705 induces differentiation in AML cell lines and primary patient samples through GSK3α-selective inhibition. BRD0705 induces differentiation.

Effect of RK‐33 on radiation‐induced DNA damage AImmunofluorescence images showing 53BP1 and γH2AX foci in A549 cells after 2‐Gy radiation and A549 cells.

Volume 22, Issue 11, Pages (November 2015)

Fig. 1 LB100 and LB102 specifically inhibit PP2A phosphatase activity and the growth of BCR-ABL+ cells. LB100 and LB102 specifically inhibit PP2A phosphatase.

Correlation of reovirus RNA/protein with proliferating tumor cells

Fig. 6 Combination therapy with LVSOD2 and LVshCTGF preserves flap volume and reduces fibrosis after RT. Combination therapy with LVSOD2 and LVshCTGF preserves.

Fig. 4 ALRN-6924 inhibits cellular proliferation and clonogenic capacity, and induces cell cycle arrest and apoptosis in AML cell lines. ALRN-6924 inhibits.

Fig. 2. BET inhibition enhances PARPi-induced DNA damage.

Effects of SYCE2 expression on DSB repair.

Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin.

Fig. 5. Mutant KRAS increases HR capacity and MEKi decreases HR capacity in RAS mutant cells, causing increased DNA damage. Mutant KRAS increases HR capacity.

The SIM domain of RAD51 is required for HR

Fig. 3. BET inhibition reduces homologous recombination.

Fig. 4 The activation of mTOR is necessary for exercise-enhanced axonal myelination in the CC region. The activation of mTOR is necessary for exercise-enhanced.

BRG1 interacts with RAD52 and regulates its accumulation at DSB sites during homologous recombination repair. BRG1 interacts with RAD52 and regulates its.

CD151-knockdown cells show an aberrant spreading response to PMA

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Targeting HR via CDK inhibition resensitizes recurrent cultures to temozolomide (TMZ). Targeting HR via CDK inhibition resensitizes recurrent cultures.

6-TG dose and time relationships for DSB formation using PFGE, demonstrating that the formation of DSBs in both MMR+ M4 and MMR− V2 cells is dose dependent.

miR can promote cardiomyocyte proliferation in the adult heart

Interaction of NHEJ and HR pathways in PCO cultures.

Fig. 7. JQ1 represses the enhancer-promoter interaction of BRCA1.

Presentation transcript:

Fig. 3. BET inhibition reduces homologous recombination. BET inhibition reduces homologous recombination. (A) Schematic illustration of HR reporter assay. SD, splice donor; SA, splice acceptor; G, green; FP, fluorescent protein; ATG, the triplet code for the amino acid methionine. (B) HR-mediated DNA repair activity, measured by HR reporter assay, in MDA-MB-231 (left), OVCAR10 (middle), and VCaP (right). Statistical analysis by Student’s t test, *P < 0.05; n = 3. Error bars represent means ± SD. (C) Schematic illustration of ssDNA staining assay. BrdU, 5-bromo-2′-deoxyuridine. (D) Representative images (left) and quantitative results (right) of IR-induced ssDNA foci formation in DMSO- or JQ1-treated MDA-MB-231 cells. Cells without BrdU incorporation were used as negative control. Scale bars, 10 μm. (E and F) Representative images (left) and quantitative results (right) of IR-induced BRCA1 (E) and RAD51 (F) foci formation in DMSO- or JQ1-treated MDA-MB-231 cells. Scale bars, 10 μm. Ten gray (Gy) of IR was used for all three cell lines. Statistical analysis by Student’s t test, *P < 0.05; n = 3 (D to F). Error bars represent means ± SD. Lu Yang et al., Sci Transl Med 2017;9:eaal1645 Published by AAAS