LICEO SCIENTIFICO FRANCESCO REDI ZENKER’S DEGENERATION TEACHER: VANNUCCINI ELISA STUDENT:MENCUCCI MARCO

MUSCLE It’s a soft tissue found in most animals. Muscle cells contain protein filaments of actin and myosin then slide past one another, producing a contraction.

MUSCLE’S TYPES: INVOLUNTARY VOLUNTARY A muscle that contracts without Muscle whose action is normally control- conscious control. led by an individual’s will Ex.: stomach Ex.: biceps and triceps

A tissue can incur in a DEGENERATION That could be: True degeneration: when there is actual chemical change of the tissue itself; Infiltration: when the change consists of the deposit of abnormal matter in the tissues.

WHO IS FRIEDRICH ALBERT VON ZENKER? Zenker (13 March 1825,Dresden-13 June 1898, Mecklenburg) was a German pathologist and physician, celebrated for his discoveries in the diseases’s field.

ZENKER’S DEGENERATION It’s a severe hyaline degeneration or necrosis of skeletal muscles, and occurs in severes cases of toxaemia as typhoid fever.

NECROSIS It’s a form of cell injury wich results in the premature death of cells in living tissue by autolysis. ONCOSIS: it is an accidental necrosis. APOPTOSIS: a voluntary necrosis.

CAUSES OF ZENKER’S DEGENERATION Thoxemia: presence of toxins in the blood (commonly called bacteremia), wich is normally a sterile environment. By the action of lactic acid wich is formed by the living muscle under the stimolation of infecting bacteria, and the accumulation of this acid could be helped by a defective circulation

TREATMENT: Debridement: removal of dead tissue by surgical or non surgical means, and in extremes cases there could be the amputation of affected limbs. Some treatments involve identification of the harmful agent followed by the use of immunosuppresive therapies. Stamina cells, wich are used just in sperimentals treatments.

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