Phase II Trial of SBRT for Stage I NSCLC: Survival, Local Control, and Lung Function at 36 Months  Arturo Navarro-Martin, MD, Samantha Aso, MD, Jon Cacicedo,

Slides:



Advertisements
Similar presentations
Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review  David.
Advertisements

Su K. Metcalfe, MD, MPH, Michael T
A Case of a Patient with Idiopathic Pulmonary Fibrosis with Lung Squamous Cell Carcinoma Treated with Nivolumab  Monica Khunger, MD  Journal of Thoracic.
Primary Signet-Ring Carcinoma (SRC) of the Lung: A Population-Based Epidemiologic Study of 262 Cases with Comparison to Adenocarcinoma of the Lung  Sai-Hong.
Brandon Stone, MD, Victor S. Mangona, MD, Matthew D
Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,
Quantification of emphysema with preoperative computed tomography has stronger association with pulmonary complications than pulmonary function test results.
Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.
SC17.02 Lung Cancer in China: Challenges and Perspectives
Role of Postoperative Radiotherapy in Pathologic Stage IIIA (N2) Non–Small Cell Lung Cancer in a Prospective Nationwide Oncology Outcomes Database  Alex.
Phase II Trial with Carboplatin and Bendamustine in Patients with Extensive Stage Small-Cell Lung Cancer  Wolf Köster, MD, Andrea Heider, MD, Norbert.
The Efficacy and Safety of BI 2536, a Novel Plk-1 Inhibitor, in Patients with Stage IIIB/IV Non-small Cell Lung Cancer Who Had Relapsed after, or Failed,
Preoperative Exercise Vo2 Measurement for Lung Resection Candidates: Results of Cancer and Leukemia Group B Protocol 9238  Gregory M. Loewen, DO, Dorothy.
Prognostic Significance of C-Reactive Protein and Smoking in Patients with Advanced Non-small Cell Lung Cancer Treated with First-Line Palliative Chemotherapy 
Validation of the Stage Groupings in the Eighth Edition of the TNM Classification for Lung Cancer  Xizhao Sui, MD, Wei Jiang, MD, Haiqing Chen, MD, Fan.
Brandon Stone, MD, Victor S. Mangona, MD, Matthew D
Is There a Lower Limit of Pretreatment Pulmonary Function for Safe and Effective Stereotactic Body Radiotherapy for Early-Stage Non-small Cell Lung Cancer? 
Randomized Phase II Study of Preoperative Chemoradiotherapy ± Panitumumab Followed by Consolidation Chemotherapy in Potentially Operable Locally Advanced.
Role of Postoperative Radiotherapy in Pathologic Stage IIIA (N2) Non–Small Cell Lung Cancer in a Prospective Nationwide Oncology Outcomes Database  Alex.
Phase II Trial of Weekly Dose-Dense Paclitaxel in Extensive-Stage Small Cell Lung Cancer: Cancer and Leukemia Group B Study 39901  Stephen L. Graziano,
Susan C. Scott, MD, Nathan A. Pennell, MD, PhD 
Patterns of Care and Treatment Outcomes of Elderly Patients with Stage I Esophageal Cancer: Analysis of the National Cancer Data Base  Amy C. Moreno,
A Case of a Patient with Idiopathic Pulmonary Fibrosis with Lung Squamous Cell Carcinoma Treated with Nivolumab  Monica Khunger, MD  Journal of Thoracic.
Megan B. Barnet, BS, M. B. B. S. , Sandra O’Toole, PhD, Lisa G
Outcome after PORT in ypN2 or R1/R2 versus no PORT in ypN0 Stage III-N2 NSCLC after Induction Chemotherapy and Resection  Charlotte Billiet, MD, Stéphanie.
Electronic Updates for JTO Readers
IA05.01 Lung Cancer Cases Journal of Thoracic Oncology
A Brief Report of the Status of Central Nervous System Metastasis Enrollment Criteria for Advanced Non–Small Cell Lung Cancer Clinical Trials: A Review.
Frank Detterbeck, MD  Journal of Thoracic Oncology 
Phase II Trial of Paclitaxel and Cisplatin in Patients with Extensive Stage Small Cell Lung Cancer: Cancer and Leukemia Group B Trial 9430  Thomas E.
Regional Emphysema Score Predicting Overall Survival, Quality of Life, and Pulmonary Function Recovery in Early-Stage Lung Cancer Patients  Jie Dai, PhD,
A Combined Prognostic Serum Interleukin-8 and Interleukin-6 Classifier for Stage 1 Lung Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening.
Bortezomib (PS-341) in Relapsed or Refractory Extensive Stage Small Cell Lung Cancer: A Southwest Oncology Group Phase II Trial (S0327)  Primo N. Lara,
Long-Term Results of a Trial of Concurrent Chemotherapy and Escalating Doses of Radiation for Unresectable Non–Small Cell Lung Cancer: NCCTG N0028 (Alliance) 
Association between Congenital Lung Malformations and Lung Tumors in Children and Adults: A Systematic Review  Arianna Casagrande, MD, Federica Pederiva,
Erik Jakobsen, Maria Iachina, Karen Ege Olsen, Anders Green 
Prospective Study on Functional Results After Lung-Sparing Radical Pleurectomy in the Management of Malignant Pleural Mesothelioma  Servet Bölükbas, MD,
Ellen Kim, MD, MPH, Siran Koroukian, PhD, Charles R. Thomas, MD 
Clinical outcomes and changes in lung function after segmentectomy versus lobectomy for lung cancer cases  Bo Deng, MD, PhD, Stephen D. Cassivi, MD, Mariza.
A Phase II Study of Paclitaxel + Etoposide + Cisplatin + Concurrent Radiation Therapy for Previously Untreated Limited Stage Small Cell Lung Cancer (E2596):
Relationship Between Functional Preservation after Segmentectomy and Volume- Reduction Effects after Lobectomy in Stage I Non-small Cell Lung Cancer Patients.
PD-L1 as a Companion Biomarker for Immune Checkpoint Inhibitors in NSCLC: Should RNA ISH (RISH) Be Considered?  Steven G. Gray, PhD  Journal of Thoracic.
Daniel Morgensztern, MD, Boone Goodgame, MD, Maria Q
Appropriateness of Surgical Approach in Black Patients with Lung Cancer—15 Years Later, Little Has Changed  Emanuela Taioli, MD, PhD, Raja Flores, MD 
Phase II Study of the Histone Deacetylase Inhibitor Romidepsin in Relapsed Small Cell Lung Cancer (Cancer and Leukemia Group B 30304)  Gregory A. Otterson,
Impact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer  Mark F. Berry, MD, Chi-Fu Jeffrey.
A Double-Blind Randomized Discontinuation Phase-II Study of Sorafenib (BAY 43– 9006) in Previously Treated Non–Small-Cell Lung Cancer Patients: Eastern.
Forced Expiratory Volume in One Second as a Prognostic Factor in Advanced Non- small Cell Lung Cancer  Jin Hwa Lee, MD, PhD, Eun Mi Song, MD, Yun Su Sim,
Trends in Stage Distribution for Patients with Non-small Cell Lung Cancer: A National Cancer Database Survey  Daniel Morgensztern, MD, Shean Huey Ng,
Clinical Relevance of Our Multimodality Prognostic Score
Long-Term Results of a Phase II Trial of Induction Paclitaxel-Carboplatin Followed by Concurrent Radiation Therapy and Weekly Paclitaxel and Consolidation.
It’s All in the “Swerve of the Curve”
Phase II Trial of Paclitaxel–Topotecan–Etoposide Followed by Consolidation Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer: CALGB 30002  Antonius.
Maintenance Therapy and Advanced Non–Small-Cell Lung Cancer: A Skeptic's View  Martin J. Edelman, MD, Thierry Le Chevalier, MD, Jean-Charles Soria, MD,
Pulmonary Resection for Metastases from Colorectal Cancer
Michael Hsie, MD, Stefania Morbidini-Gaffney, MD, Leslie J
Roger Hakimian, MD, Hongbin Fang, PhD, Leno Thomas, MD, Martin J
A Phase II Study of Carboplatin, Etoposide, and Exisulind in Patients with Extensive Small Cell Lung Cancer: CALGB 30104  Ramaswamy Govindan, MD, Xiaofei.
Impact of Sublobar Resection on Pulmonary Function: Long-Term Results from American College of Surgeons Oncology Group Z4032 (Alliance)  Michael S. Kent,
Wedge Resection for Non-small Cell Lung Cancer in Patients with Pulmonary Insufficiency: Prospective Ten-Year Survival  John P. Griffin, MD, Charles E.
Genetic and Proteomic Features Associated with Survival after Treatment with Erlotinib in First-Line Therapy of Non-small Cell Lung Cancer in Eastern.
Liseth L. van den Berg, MD, Theo J. Klinkenberg, MD, Harry J. M
Surveillance Epidemiology and End Results Evaluation of the Role of Surgery for Stage I Small Cell Lung Cancer  James B. Yu, MD, Roy H. Decker, MD, PhD,
A Randomized, Phase II Trial of Two Dose Levels of Temsirolimus (CCI-779) in Patients with Extensive-Stage Small-Cell Lung Cancer Who Have Responding.
Is pulmonary function damaged by neoadjuvant lung cancer therapy
Population-Based Patterns of Surgical Care for Stage IIIA NSCLC in the Netherlands between 2010 and 2013  Chris Dickhoff, MD, Max Dahele, MBChB., PhD,
Phase-II Trial of Rebeccamycin Analog, a Dual Topoisomerase-I and -II Inhibitor, in Relapsed “Sensitive” Small Cell Lung Cancer  Anita Schwandt, MD, Tarek.
Robert Comis, MD, The Passing of a “Lung Man”
Local Control and Toxicity of Adaptive Radiotherapy Using Weekly CT Imaging: Results from the LARTIA Trial in Stage III NSCLC  Sara Ramella, MD, Michele.
Reply to “Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non–Small Cell Lung Cancer: Methodological Issues”  Boris Sepesi,
Presentation transcript:

Phase II Trial of SBRT for Stage I NSCLC: Survival, Local Control, and Lung Function at 36 Months  Arturo Navarro-Martin, MD, Samantha Aso, MD, Jon Cacicedo, PhD, Maria Arnaiz, MD, Valentin Navarro, MD, Samuel Rosales, MD, Rodolfo de Blas, PhD, Ricard Ramos, PhD, Ferran Guedea, PhD  Journal of Thoracic Oncology  Volume 11, Issue 7, Pages 1101-1111 (July 2016) DOI: 10.1016/j.jtho.2016.03.021 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 CONSORT diagram. Journal of Thoracic Oncology 2016 11, 1101-1111DOI: (10.1016/j.jtho.2016.03.021) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Kaplan-Meier analysis. (A) Local control, (B) regional control, (C) overall survival, and (D) cancer-specific survival. Journal of Thoracic Oncology 2016 11, 1101-1111DOI: (10.1016/j.jtho.2016.03.021) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Box and whisker plots of changes in pulmonary function over time. (A) Absolute values of forced expiratory volume in 1 second (FEV1), (B) absolute values of forced expiratory vital capacity (FVC), and (C) percentage of diffusing capacity for carbon monoxide (Dlco). Journal of Thoracic Oncology 2016 11, 1101-1111DOI: (10.1016/j.jtho.2016.03.021) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions