Optimizing Accuracy of Laboratory Testing: Team-Based Strategies to Reduce Biotin Concerns.

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Presentation transcript:

Optimizing Accuracy of Laboratory Testing: Team-Based Strategies to Reduce Biotin Concerns

Physicians Rely on Accurate Laboratory Results

Emerging Problem of Biotin Interference in Immunoassays

Dietary Sources

Laboratory Errors Can Occur in the 3 Phases of the Testing Process

Sources of Analytical Error in Clinical Immunoassays

Biotin: Interference in Immunoassays

Non-Competitive Immunoassays

Competitive Immunoassays

Noncompetitive vs Competitive Immunoassay

Interference Example

UCDMC Endocrinology Population

UC Davis Thyroid Testing Population

Biotin in TSH and Troponin Testing

Biotin in TSH and Troponin Testing (cont)

Affected Laboratory Testing

High-Sensitivity Cardiac Troponin Assay

UC Davis Summary

Key Point: Biotin Interference Is Preventable

Health History: Avoid Issues Later

Ask When Was Biotin Taken

Educate All Disciplines on Many Platforms

Multidisciplinary Team System Approaches

Key Takeaways: Clinicians' Responsibilities

Attention Emergency Medicine Clinicians

Rare But Be Aware

Abbreviations