Cardiac Myeloid Sarcoma: Multimodality Radiologic Imaging Features and Pathologic Correlation Daniela Dörfel, MD, Maik Häntschel, MD, Birgit Federmann,

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Presentation transcript:

Cardiac Myeloid Sarcoma: Multimodality Radiologic Imaging Features and Pathologic Correlation Daniela Dörfel, MD, Maik Häntschel, MD, Birgit Federmann, MD, Susanne Haen, MD, Falko Fend, MD, Iris I. Müller, MD, Helmut R. Salih, MD, Wichard Vogel, MD, Lothar Kanz, MD, Marius Horger, MD The American Journal of Medicine Volume 129, Issue 8, Pages e117-e120 (August 2016) DOI: 10.1016/j.amjmed.2016.03.028 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Apical 4-chamber view obtained by 2-dimensional echocardiography. White arrows mark the borders of the epicardial tumor masses infiltrating the lateral wall of the right ventricle and the right atrium. LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle. The American Journal of Medicine 2016 129, e117-e120DOI: (10.1016/j.amjmed.2016.03.028) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Volume perfusion computed tomography clearly demonstrates both right and left nodular ventricular myocardial infiltration by myeloid sarcoma. The American Journal of Medicine 2016 129, e117-e120DOI: (10.1016/j.amjmed.2016.03.028) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Macroscopic view of the left ventricle, showing the infiltrated myocardium and endocardium. The American Journal of Medicine 2016 129, e117-e120DOI: (10.1016/j.amjmed.2016.03.028) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 4 Morphology and immunohistochemistry. (A) Infiltration of the myocardium by atypical large cells with a high nuclear/cytoplasmic (hematoxylin and eosin; original magnification ×200). (B) Myeloperoxidase (×400), (C) Chloracetate esterase stain (×400) highlight the myeloid differentiation of the blasts, and (D) CD68–KP1 (×400) shows a variable expression. The American Journal of Medicine 2016 129, e117-e120DOI: (10.1016/j.amjmed.2016.03.028) Copyright © 2016 Elsevier Inc. Terms and Conditions