Triiodothyronine reverses depressed contractile performance after excessive catecholamine stimulation Tomasz Timek, MD, Christian-Friedrich Vahl, MD,

Slides:

Advertisements

Similar presentations

Mechanisms of Myocardial Contraction Dr. B. Tuana.

Advertisements

PHYSIOLOGY 1 LECTURE 24 CARDIAC MUSCLE MECHANICS.

George E. Yanulis, MEng, MS, Pascal Lim, MD, Ali Ahmad, MD, Zoran B

Madhu Prasad, Jeffrey B. Matthews, Xue D. He, Hamid I. Akbarali

Use of intermediate/small conductance calcium-activated potassium-channel activator for endothelial protection Qin Yang, MD, PhD, Jun-Hao Huang, MPhil,

What does the following have in common?

Christian Rosenmund, Charles F Stevens Neuron

Bone Morphogenic Protein-4 Contributes to Venous Endothelial Dysfunction in Patients With Diabetes Undergoing Coronary Revascularization Jia Hu, MD,

Diastolic heart failure in anaesthesia and critical care

Endothelium-Dependent Vasoconstriction in Isolated Vessel Grafts: A Novel Mechanism of Vasospasm? Markus Hoenicka, PhD, Andreas Keyser, MD, Leopold Rupprecht,

Effect of Benidipine in Human Internal Mammary Artery and Clinical Implications Hai-Tao Hou, BE, Jun Wang, BA, Zheng-Qing Wang, MD, Xiao-Cheng Liu, MD,

Activation of Kinetically Distinct Synaptic Conductances on Inhibitory Interneurons by Electrotonically Overlapping Afferents Harrison C. Walker, J.Josh.

Calcium-Dependent Facilitation and Graded Deactivation of Store-Operated Calcium Entry in Fetal Skeletal Muscle Claude Collet, Jianjie Ma Biophysical.

Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects Jay G. Shake, MD, Peter J. Gruber, MD, PhD,

Thomas V Bilfinger, MD, George B Stefano, PhD

A Role of Intracellular Na+ in the Regulation of Synaptic Transmission and Turnover of the Vesicular Pool in Cultured Hippocampal Cells Alexandre Bouron,

Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part I. Physiologic and Pathophysiologic.

George E. Yanulis, MEng, MS, Pascal Lim, MD, Ali Ahmad, MD, Zoran B

Volume 107, Issue 10, Pages (November 2014)

Ventricular septal rupture caused by myocardial bridging

Differential Effects of Protein Kinase C Isoform Activation in Endothelin-Mediated Myocyte Contractile Dysfunction With Cardioplegic Arrest and Reperfusion

Cellular mechanisms of cyclic nucleotide-induced vasorelaxation

Regulation of Human Internal Mammary and Radial Artery Contraction by Extracellular and Intracellular Calcium Channels and Cyclic Adenosine 3′, 5′ Monophosphate

Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study Julius M Guccione, PhD, Ali Salahieh,

Ischemic preconditioning is not cardioprotective in senescent human myocardium Babett Bartling, PhD, Ivar Friedrich, MD, Rolf-E Silber, MD, Andreas Simm,

Temporary Atrial Electrode for the Treatment of Supraventricular Tachycardia After Cardiac Operations Hormoz Mehmanesh, Rüdiger Lange, Siegfried Hagl

Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1 Paul J. Pearson,

Catherine I. Chardigny, MD, Victor A. Jebara, MD, Tony J

Isolated fracture of the ventricular septum after blunt chest trauma

Depolarizing cardiac arrest and endothelium-derived hyperpolarizing factor–mediated hyperpolarization and relaxation in coronary arteries: The effect.

In vivo validation of cardiac spiral computed tomography using retrospective gating Jörg Albers, MD, Jan M Boese, PhD, Christian F Vahl, MD, Siegfried.

Regulation of the aortic valve opening

Ventricular assist device programs: design and function

Volume 79, Issue 2, Pages (August 2000)

Downstream defects in β-adrenergic signaling and relation to myocyte contractility after cardioplegic arrest Ward V. Houck, MD, Chadwick V. Thomas, BS,

Volume 6, Issue 8, Pages (August 1996)

Guo-Wei He, MD, DSc, David P. Taggart, FRCS

Edmund J. Crampin, Nicolas P. Smith Biophysical Journal

J. Darcy O'Brien, MS, Susan E. Howlett, PhD, Hayley J

Interplay of Troponin- and Myosin-Based Pathways of Calcium Activation in Skeletal and Cardiac Muscle: The Use of W7 as an Inhibitor of Thin Filament.

Volume 16, Issue 3, Pages (March 1996)

Mehrdad M. R. Amirhamzeh, MD, David A

Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia Stacy B. O’Blenes, MD, Camille Hancock Friesen, MD,

Volume 68, Issue 5, Pages (November 2005)

Heme oxygenase: protective enzyme or portal hypertensive molecule?

Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs Jiang-Yong.

Mechanical properties of human saphenous veins from normotensive and hypertensive patients Veronica Milesi, PhD, Alejandro Rebolledo, BSc, Felix Ayala.

Volume 9, Issue 1, Pages (January 2012)

Sarpogrelate inhibits serotonin-induced proliferation of porcine coronary artery smooth muscle cells: implications for long-term graft patency Sushil.

Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia Ares D. Pasipoularides, MD, PhD, Ming.

Cellular mechanisms of ischemia-reperfusion injury

Gregory A Thomas, MD, Larry W Stephenson, MD

R. Stehle, M. Krüger, G. Pfitzer Biophysical Journal

Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine Helmut Habazettl, MD, Barbara W. Palmisano,

Role of Endothelin-1 Receptor Antagonists in Vasoconstriction Mediated by Endothelin and Other Vasoconstrictors in Human Internal Mammary Artery Guo-Wei.

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin,

Inhibitory effect of milrinone on cytokine production after cardiopulmonary bypass Nobuhiko Hayashida, MD, PhD, Hiroshi Tomoeda, MD, Takeshi Oda, MD,

Cellular and molecular therapeutic targets for treatment of contractile dysfunction after cardioplegic arrest Francis G Spinale, MD, PhD The Annals.

Physiologic left ventricular reconstruction: Shape, function, and time recaptured Gerald D. Buckberg, MD The Journal of Thoracic and Cardiovascular Surgery

A new method of double cardiomyoplasty: “contractile muscular sling”

Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies Ben M Tsai, MD, Meijing Wang, MD, Mark W Turrentine,

Christian Rosenmund, Charles F Stevens Neuron

Ross-Konno Operation With Resection of Endocardial Fibroelastosis for Critical Aortic Stenosis With Borderline-Sized Left Ventricle in Neonates Jacques.

Neal S Goldstein, MD The Annals of Thoracic Surgery

Left ventricular functional improvement after transmyocardial laser revascularization Keith A Horvath, MD, Rodney Greene, BS, Noam Belkind, Bonnie Kane,

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Assessment of Sarcoplasmic Reticulum Ca2+ Depletion During Spontaneous Ca2+ Waves in Isolated Permeabilized Rabbit Ventricular Cardiomyocytes N. MacQuaide,

Long-term outcome after coronary artery bypass grafting in patients with severe left ventricular dysfunction John Alfred Carr, MD, Benjamin E Haithcock,

Reversal of protein-losing enteropathy with calcium replacement in a patient after Fontan operation Soo-Jin Kim, MD, In-Seung Park, MD, Jin-Young Song,

Volume 78, Issue 6, Pages (June 2000)

Presentation transcript:

Triiodothyronine reverses depressed contractile performance after excessive catecholamine stimulation Tomasz Timek, MD, Christian-Friedrich Vahl, MD, Andreas Bonz, MD, Leo Schäffer, Mark Rosenberg, Siegfried Hagl, MD The Annals of Thoracic Surgery Volume 66, Issue 5, Pages 1618-1625 (November 1998) DOI: 10.1016/S0003-4975(98)00764-4

Fig 1 Superimposed isometric contractions of isolated trabeculae before (1) and after (2) triiodothyronine (T3) incubation in a normal porcine left ventricular muscle fiber. The slight abbreviation and the increase of the amplitude of the intracellular calcium transient and the acceleration of the time course of the isometric contraction are clearly visible. The Annals of Thoracic Surgery 1998 66, 1618-1625DOI: (10.1016/S0003-4975(98)00764-4)

Fig 2 Effect of triiodothyronine (T3) application in an isolated porcine left ventricular trabeculum that was incubated for 6 hours with epinephrine. Note that after T3 application the isometric force amplitude (upper trace) and the amplitude of shortening (lower trace) increased considerably. (Epi = epinephrine.) The Annals of Thoracic Surgery 1998 66, 1618-1625DOI: (10.1016/S0003-4975(98)00764-4)

Fig 3 Illustration of the effect of triiodothyronine (T3) application after a 6-hour period of epinephrine incubation on intracellular calcium transient and force as illustrated by an original recording. Note that systolic calcium (peak value of the calcium transient) remains nearly unaltered in this muscle, while diastolic calcium declines. This is accompanied by a dramatic decline of resting tension and a considerable increase of the isometric force amplitude. (Epi = epinephrine.) The Annals of Thoracic Surgery 1998 66, 1618-1625DOI: (10.1016/S0003-4975(98)00764-4)

Fig 4 Digitized and averaged recordings of 60 sequential isometric contractions before and after triiodothyronine (T3) application (upper trace, intracellular calcium transient; lower trace, isometric force). Trace (1) represents averaged recordings after long-term, high-dose epinephrine exposure; curve (2) indicates recordings measured after T3 application. Note that after T3 treatment the amplitude of the intracellular calcium transient declines considerably. The diastolic decay of the calcium transient is accelerated. However, despite the considerable reduction of the amplitude of the intracellular calcium transient the force amplitude did not decline. There was even a slight increase. The time course of both contraction and relaxation was accelerated. An unchanged force amplitude measured at a reduced intracellular calcium transient provides direct evidence that the contractile apparatus becomes more sensitive to calcium after T3 application (sensitization of the contractile apparatus to calcium). (Epi = epinephrine.) The Annals of Thoracic Surgery 1998 66, 1618-1625DOI: (10.1016/S0003-4975(98)00764-4)

Fig 5 Illustration of some effects mediated by high-dose catecholamine stimulation. Improved contractile performance is caused by increased intracellular calcium levels after catecholamine stimulation. When catecholamine exposure persists a cyclic adenosine monophosphate (cAMP)-dependent phopsphorylation of troponin I is induced, which in turn is associated with negative inotropic effects (reduced calcium sensitivity of the contractile apparatus and retarded actomyosin adenosine triphosphatase activity). A parallel cAMP-dependent phosphorylation of myosin light chains (LC) induces an enhancement of the myofibrillar adenosine triphosphatase activity correlating positively with the contractile performance. The catalytic activity of the protein phosphatase 2B increases with rising intracellular calcium concentrations and acts on phosphorylated myosin-light chains when intracellular calcium remains elevated. As a result the negative inotropic effect of troponin I phosphorylation overrides the positive effects of myosin light chain phosphorylation when both phosphorylation processes occur in the presence of high intracellular calcium loads. The Annals of Thoracic Surgery 1998 66, 1618-1625DOI: (10.1016/S0003-4975(98)00764-4)