Why does the fallopian tube fail in ectopic pregnancy

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Why does the fallopian tube fail in ectopic pregnancy Why does the fallopian tube fail in ectopic pregnancy? The role of activins, inducible nitric oxide synthase, and MUC1 in ectopic implantation Bassem Refaat, Ph.D., Hannah Simpson, B.Med.Sci., Elizabeth Britton, B.Med.Sci., Jhulan Biswas, M.D., Michael Wells, M.D., John D. Aplin, Ph.D., William Ledger, D.Phil. Fertility and Sterility Volume 97, Issue 5, Pages 1115-1123 (May 2012) DOI: 10.1016/j.fertnstert.2012.02.035 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Expression of (A–E) activin-βA subunit, (F–J) IIA receptor, and (K–O) IIB receptor in fallopian tube specimens collected during the luteal phase (first row from top), pseudopregnancy (second row), and from a remote site (third row) and the implantation site (fourth row) collected from ectopic pregnancies and from chorionic villi (fifth row). All parts, magnification: ×400, scale bar = 8 μm. Fertility and Sterility 2012 97, 1115-1123DOI: (10.1016/j.fertnstert.2012.02.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Expression of (A–E) inducible nitric oxide synthase (iNOS), (F–J) MUC1 214D4, and (K–O) BC2 in fallopian tube specimens collected during the luteal phase (first row from top), pseudopregnancy (second row), and from a remote site (third row) and the implantation site (fourth row) collected from ectopic pregnancies and chorionic villi (fifth row). All parts, magnification: ×400, scale bar = 8 μm. Fertility and Sterility 2012 97, 1115-1123DOI: (10.1016/j.fertnstert.2012.02.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Relative concentration of messenger RNA expression of (A) activin-βA subunit, (B) activin type IIA and (C) IIB receptors, (D) iNOS, and (E) MUC1 in fallopian tube epithelial cells collected during the luteal phase, pseudopregnancy, and from remote and implantation sites collected from ectopic pregnancies. aP<.05 versus luteal phase. bP<.05 versus pseudopregnancy. cP<.05 versus remote site. Fertility and Sterility 2012 97, 1115-1123DOI: (10.1016/j.fertnstert.2012.02.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions