Joanne M. Hildebrand, James M. Murphy  Immunity 

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The Highway to Hell: A RIP Kinase-Directed Shortcut to Inflammatory Cytokine Production  Joanne M. Hildebrand, James M. Murphy  Immunity  Volume 45, Issue 1, Pages 1-3 (July 2016) DOI: 10.1016/j.immuni.2016.06.029 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The RIPK1-RIPK3 Necrosome Triggers Both Inflammatory Cytokine Production and Necroptosis Downstream of TLR4-TRIF While necrosome mediated Erk1/2 phosphorylation and MLKL phosphorylation is concurrent, Erk1/2 induces inflammatory gene induction at break-neck speed while MLKL takes a more meandering path to necroptotic membrane destruction. Immunity 2016 45, 1-3DOI: (10.1016/j.immuni.2016.06.029) Copyright © 2016 Elsevier Inc. Terms and Conditions

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