Volume 21, Issue 7, Pages (July 2013)

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Volume 21, Issue 7, Pages 1294-1296 (July 2013) Exosome-like Nanoparticles From Food: Protective Nanoshuttles for Bioactive Cargo Michel Record Molecular Therapy Volume 21, Issue 7, Pages 1294-1296 (July 2013) DOI: 10.1038/mt.2013.130 Copyright © 2013 The American Society of Gene & Cell Therapy Terms and Conditions

Figure 1 From grapes to exosome-like nanovesicles. Regular grapes contain nanovesicles that can be isolated after crushing by ultracentrifugation. When orally administrated to mice, grape exosome-like nanoparticles (GELNs) can pass through the digestive tract and trigger recovery of chemically induced colitis. GELNs enter intestinal stem cells by macropinocytosis and stimulate their proliferation both by activation of the Wnt/β-catenin/GSK3 pathway and by the mitogenic lipid phosphatidic acid, whose effect might involve the mammalian target of rapamycin (mTOR) complex. DSS, dextran sodium sulfate; LEF, lymphoid enhancer factor; TCF, T-cell factor. Molecular Therapy 2013 21, 1294-1296DOI: (10.1038/mt.2013.130) Copyright © 2013 The American Society of Gene & Cell Therapy Terms and Conditions