Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations Dennis G. Moledina, MBBS, Selin Isguven,

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Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations Dennis G. Moledina, MBBS, Selin Isguven, BS, Eric McArthur, MS, Heather Thiessen-Philbrook, MMath, Amit X. Garg, MD, PhD, Michael Shlipak, MD, Richard Whitlock, MD, Peter A. Kavsak, PhD, Steven G. Coca, MD, MS, Chirag R. Parikh, MD, PhD The Annals of Thoracic Surgery Volume 104, Issue 2, Pages 613-620 (August 2017) DOI: 10.1016/j.athoracsur.2016.11.036 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) Monocyte chemotactic protein-1 (MCP-1) levels are significantly higher in patients with acute kidney injury (AKI). *p < 0.001 at all time-points. (B) MCP-1 levels are significantly higher in those who died. *p = 0.001 on the preoperative time point, p = 0.02 on the first postoperative day, and p < 0.001 at all other time points. The top and bottom of the box represent the interquartile range, and the horizontal line represents the median. Day 1 refers to 0 to 6 hours after the operation, day 2 corresponds to 48 hours after the operation, and day 3 corresponds to 72 hours after the operation. The Annals of Thoracic Surgery 2017 104, 613-620DOI: (10.1016/j.athoracsur.2016.11.036) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Probability of death after a cardiac operation by preoperative monocyte chemotactic protein-1 (MCP-1) tertiles (T). (B) Probability of death after a cardiac operation by postoperative MCP-1 tertiles. MCP-1 tertile cutoffs (pg/mL): Preoperative: T1, 12 to 147; T2, 147 to 196; T3, 196 to 1,581. Postoperative: T1, 40 to 359; T2, 359 to 600; T3, 600 to 1,581. Median length of follow-up was 2.9 years (interquartile range, 2.2 to 3.5 years). The Annals of Thoracic Surgery 2017 104, 613-620DOI: (10.1016/j.athoracsur.2016.11.036) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions