Remodeling Amyloid Fibers: Baker’s Yeast Shows Us the Way

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Presentation transcript:

Remodeling Amyloid Fibers: Baker’s Yeast Shows Us the Way Eva Asp, Ming Proschitsky, Rajaraman Krishnan Chemistry & Biology Volume 22, Issue 8, Pages 979-981 (August 2015) DOI: 10.1016/j.chembiol.2015.08.001 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Hsp104 Mediated Clustering and Remodeling of Seminal Amyloids Hsp104 mediated remodeled aggregates can be degraded efficiently in the presence of cellular proteases. Chemistry & Biology 2015 22, 979-981DOI: (10.1016/j.chembiol.2015.08.001) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Schematic Representation of Amyloid Remodeling Nanomachines The substrate binding domain (SBD) and conformational change inducing domain (CID) work in tandem to bind and remodel fibers. SlyD, g3p, and FkpA are alternate scaffolds that can be engineered to bind and remodel aggregates. Chemistry & Biology 2015 22, 979-981DOI: (10.1016/j.chembiol.2015.08.001) Copyright © 2015 Elsevier Ltd Terms and Conditions