Chronic pulmonary artery occlusion increases alveolar fluid clearance in rats Zheng Wang, MD, Jin Xu, MD, Gang Ma, MD, Motoyasu Sagawa, MD, PhD, Miyako.

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Presentation transcript:

Chronic pulmonary artery occlusion increases alveolar fluid clearance in rats Zheng Wang, MD, Jin Xu, MD, Gang Ma, MD, Motoyasu Sagawa, MD, PhD, Miyako Shimazaki, BS, Yoshimichi Ueda, MD, PhD, Tsutomu Sakuma, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 134, Issue 5, Pages 1213-1219 (November 2007) DOI: 10.1016/j.jtcvs.2007.05.027 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The effect of pulmonary artery occlusion on lung water volume (A), alveolar fluid clearance (B), on Na,K-ATPase mRNA (C and D),and protein levels (E). Left pulmonary artery occlusion increased both the lung water/dry lung weight ratio (A) and alveolar fluid clearance (percent of instilled volume over 1 hour, B) in the left lungs, but not in the right lungs, in rats with left pulmonary artery occlusion. RT-PCR demonstrated that left pulmonary artery occlusion increased the α1-Na,K-ATPase mRNA levels (C), but not β1-Na,K-ATPase mRNA levels (D), in the left lungs in rats with left pulmonary artery occlusion. The protein levels of α1-Na,K-ATPase, but not β1-Na,K-ATPase, increased in the left lung in rats with pulmonary artery occlusion (occlusion, n = 2) compared with the left lungs in sham control (control, n = 2) (E). *P <.05 vs sham control and right lungs in rats with pulmonary artery occlusion. †P <.01 vs values of Na,K-ATPase mRNA over GAPDH mRNA in the right lungs in rats with left pulmonary artery occlusion and in sham rats without pulmonary artery occlusion. Means ± standard errors. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 1213-1219DOI: (10.1016/j.jtcvs.2007.05.027) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 The effects of terbutaline and propranolol on alveolar fluid clearance in rats with left pulmonary artery occlusion (A). Terbutaline (10−6 mol/L) increased alveolar fluid clearance in the right lungs, but not in the left lungs, in rats with left pulmonary artery occlusion. Propranolol (10−4 mol/L) had no effect on alveolar fluid clearance in both lungs in rats with left pulmonary artery occlusion. *P <.05 vs the rates of alveolar fluid clearance in the right lungs in rats with pulmonary artery occlusion. None, No treatment of propranolol or terbutaline. The effect of pulmonary artery occlusion on β2-adrenoceptor mRNA level (B). RT-PCR demonstrated that the level of β2-adrenoceptor mRNA over GAPDH mRNA decreased in the left lungs in rats with left pulmonary artery occlusion. *P < .05 vs the mRNA levels in the right lungs in rats with left pulmonary artery occlusion and in bilateral lungs in control rats. Means ± standard errors. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; RT-PCR, real-time polymerase chain reaction; mRNA, messenger ribonucleic acid. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 1213-1219DOI: (10.1016/j.jtcvs.2007.05.027) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Morphologic examination of the lungs in rats with pulmonary artery occlusion for 14 days. Periarterial cuffing was absent in the right lungs (A) but present in the left lungs (B, ×100, C, ×200) in rats without pulmonary perfusion. Arrows, Perivascular cuffing. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 1213-1219DOI: (10.1016/j.jtcvs.2007.05.027) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions