Volume 139, Issue 3, Pages e1 (September 2010)

Slides:

Advertisements

Similar presentations

Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells Lin Wang, Xiangdong Wang, Lei.

Advertisements

Volume 144, Issue 4, Pages e1 (April 2013)

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Pancreatic Fusion Abnormality Found During a Whipple Procedure

Sunjoo Boo, RN, PhD, Erika Sivarajan Froelicher, RN, PhD, FAAN

Volume 148, Issue 4, Pages (April 2015)

Flavia D. Mendes, Ayako Suzuki, Schuyler O. Sanderson, Keith D

Volume 153, Issue 3, Pages e7 (September 2017)

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Volume 153, Issue 3, Pages e7 (September 2017)

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Effectiveness of Hepatitis B Treatment in Clinical Practice

Outcomes Among Living Liver Donors

Volume 144, Issue 4, Pages e1 (April 2013)

Volume 149, Issue 2, Pages (August 2015)

Pancreatic Fusion Abnormality Found During a Whipple Procedure

Cause-Specific Mortality of People With Barrett's Esophagus Compared With the General Population: A Population-Based Cohort Study Masoud Solaymani–Dodaran,

Volume 139, Issue 6, Pages e2 (December 2010)

Volume 146, Issue 4, Pages e1 (April 2014)

The Changing Liver Transplant Waitlist: An Emerging Liver Purgatory?

Unusual Case of an Upset Stomach

Volume 153, Issue 3, Pages e16-e17 (September 2017)

Volume 135, Issue 4, Pages (October 2008)

Volume 150, Issue 4, Pages (April 2016)

Sunjoo Boo, RN, PhD, Erika Sivarajan Froelicher, RN, PhD, FAAN

Trends in Hospitalization for Diverticulitis and Diverticular Bleeding in the United States From 2000 to 2010 Chelle L. Wheat, Lisa L. Strate Clinical.

Volume 155, Issue 5, Pages e2 (November 2018)

Volume 151, Issue 1, Pages e5 (July 2016)

Sonia Radunz, Hideo A. Baba, Georgios C. Sotiropoulos Gastroenterology

A Rare Cause of Postprandial Abdominal Pain and Nausea

Volume 155, Issue 5, Pages e6 (November 2018)

Obesity and Alcohol Synergize to Increase the Risk of Incident Hepatocellular Carcinoma in Men Rohit Loomba, Hwai-I. Yang, Jun Su, David Brenner, Uchenna.

Volume 136, Issue 4, Pages e2 (April 2009)

Volume 139, Issue 1, Pages e24 (July 2010)

Volume 139, Issue 5, Pages e6 (November 2010)

An Unusual Case Presented With Multiple Liver Cystic Lesions

Impact of New Hepatitis C Treatments in Different Regions of the World

Postprandial Uridine Physiology Is Altered by Obesity

Genome-Wide Association Studies: Present Status and Future Directions

High Prevalence of Hepatic Fibrosis, Measured by Elastography, in a Population-Based Study of Mexican Americans Gordon P. Watt, Miryoung Lee, Jen-Jung.

Nicolas Goossens, Yujin Hoshida Gastroenterology

Volume 149, Issue 7, Pages (December 2015)

Genetic Testing for Hereditary Colorectal Cancer: Challenges in Identifying, Counseling, and Managing High-Risk Patients Elena M. Stoffel, Anu Chittenden

Haplotypes at ATM Identify Coding-Sequence Variation and Indicate a Region of Extensive Linkage Disequilibrium Penelope E. Bonnen, Michael D. Story,

Hashem El–Serag, Anna S.F. Lok, David L. Thomas Gastroenterology

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Association of Nonalcoholic Fatty Liver Disease With Visceral Adiposity but Not Coronary Artery Calcification in the Elderly Kathleen Jacobs, Sharon.

Jeremy P. Dwyer, Patrick Hosking, John Lubel Gastroenterology

Volume 149, Issue 6, Pages (November 2015)

Was That Last Colonoscopy Really Negative

Refining Sample-Size Estimations Based Upon Placebo Response in Trials of Agents for Nonalcoholic Fatty Liver Disease Veeral Ajmera, MD, MAS, Rohit Loomba,

Fasiha Kanwal, Jennifer R

Volume 154, Issue 1, Pages e2 (January 2018)

Statin Therapy Improves Sustained Virologic Response Among Diabetic Patients With Chronic Hepatitis C Gowtham A. Rao, Prashant K. Pandya Gastroenterology

The Dawning of a New Editorial Board for Gastroenterology

Javier Oliver, Blanca Rueda, Miguel A

Volume 148, Issue 5, Pages e4 (May 2015)

Risks Associated With Anesthesia Services During Colonoscopy

Daniel Mønsted Shabanzadeh, Lars Tue Sørensen, Torben Jørgensen

Would Free Fatty Acids Enhance Treatment of Obesity?

Volume 145, Issue 5, Pages e3 (November 2013)

Volume 139, Issue 6, Pages e1 (December 2010)

Genetic Polymorphisms in the Polycomb Group Gene EZH2 and the Risk of Lung Cancer Kyong-Ah Yoon, MD, Hye Jin Gil, MS, Jihye Han, MS, Jaehee Park, MS,

Volume 138, Issue 6, Pages (May 2010)

A Necrotic Liver Mass Gastroenterology

Volume 143, Issue 5, Pages (November 2012)

Electronic Clinical Challenges and Images in GI

Electronic Clinical Challenges and Images in GI

Controversies in Liver Transplantation for Hepatitis C

A Rare Tumor of the Liver With a Sudden Presentation

Presentation transcript:

Volume 139, Issue 3, Pages 836-845.e1 (September 2010) Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins Rohit Loomba, Fangwen Rao, Lian Zhang, Srikrishna Khandrika, Michael G. Ziegler, David A. Brenner, Daniel T. O'Connor Gastroenterology Volume 139, Issue 3, Pages 836-845.e1 (September 2010) DOI: 10.1053/j.gastro.2010.06.009 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Heritability (h2) estimates of γ-glutamyl transpeptidase (GGT) and fatty liver risk factors are shown in the present twin cohort. These h2 estimates (±standard error of mean) are similar to previously published studies, suggesting generalizability of findings from our cohort. GGT has substantial heritability, at 49% ± 8%. BMI, body mass index; DBP, diastolic blood pressure; LDL, low-density lipoprotein. Gastroenterology 2010 139, 836-845.e1DOI: (10.1053/j.gastro.2010.06.009) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Linkage disequilibrium (LD) across the β2-adrenergic receptor (ADRB2) locus using Haploview. Darker block color denotes stronger pair-wise correlation among single nucleotide polymorphisms, within one major LD block. Gastroenterology 2010 139, 836-845.e1DOI: (10.1053/j.gastro.2010.06.009) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 (A) β2-adrenergic receptor (ADRB2) haplotype-1 (AGGCCGGGC) effect on γ-glutamyl transpeptidase (GGT) in age-/sex-adjusted models. Results demonstrate a significant association (P < .024), suggesting that ADRB2 plays a role in regulation of GGT secretion. (B) ADRB2 haplotype-1 (AGGCCGGGC) increases both GGT and triglycerides in plasma. Results illustrate the pleiotropic effect of ADRB2 genetic variation on fatty liver risk factors. Gastroenterology 2010 139, 836-845.e1DOI: (10.1053/j.gastro.2010.06.009) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 ADRB2 haplotype (AGGCCGGGC) excluding HWE-violating SNP (T-47C) increases both GGT and triglycerides in plasma. Results illustrate the pleiotropic effect of ADRB2 genetic variation on fatty liver risk factors. Gastroenterology 2010 139, 836-845.e1DOI: (10.1053/j.gastro.2010.06.009) Copyright © 2010 AGA Institute Terms and Conditions