Volume 137, Issue 4, Pages (October 2009)

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Volume 137, Issue 4, Pages 1270-1279 (October 2009) Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma Frank A. Sinicrope, Rafaela L. Rego, Stephen M. Ansell, Keith L. Knutson, Nathan R. Foster, Daniel J. Sargent Gastroenterology Volume 137, Issue 4, Pages 1270-1279 (October 2009) DOI: 10.1053/j.gastro.2009.06.053 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 (Top) FoxP3+ T lymphocytes (brown color) are seen in peritumoral stroma and infiltrating epithelial cells of a sporadic colon carcinoma using immunohistochemistry (original magnification 400×). (Inset) Dual staining for FoxP3+ (nuclear) and CD4+ (cytoplasm) are seen in colon carcinoma cells using immunofluorescence microscopy. (Bottom) Epithelial and stromal CD3+ T lymphocytes are shown in a colon carcinoma at light microscopy (original magnification 400×). Gastroenterology 2009 137, 1270-1279DOI: (10.1053/j.gastro.2009.06.053) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 (Top) Density of intraepithelial versus stromal (A) FoxP3+, (B) CD3+, or (C) the CD3+/FoxP3+ T-lymphocyte ratio in TNM stages II and III colon carcinomas. (Bottom) Comparison of the density of FoxP3+ T lymphocytes infiltrating (A) tumor epithelia, (B) stroma, and (C) the epithelial to stromal ratio in DNA MMR-deficient versus MMR-proficient colon carcinomas. Box plots show median values, interquartile ranges, and extreme values (error bars). Gastroenterology 2009 137, 1270-1279DOI: (10.1053/j.gastro.2009.06.053) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Association of intraepithelial (A) FoxP3+, (B) CD3+ TILs or (C) the CD3+/FoxP3+ ratio with DFS in patients with TNM stage II and III colon carcinomas. Data are dichotomized by quartiles into high (greater than first quartile) and low (first quartile or lower) groups as shown. Gastroenterology 2009 137, 1270-1279DOI: (10.1053/j.gastro.2009.06.053) Copyright © 2009 AGA Institute Terms and Conditions