TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X- Irradiation  Helena Pópulo, Paula Boaventura, João Vinagre, Rui Batista, Adélia Mendes, Regina Caldas, Joana Pardal, Filomena Azevedo, Mrinalini Honavar, Isabel Guimarães, José Manuel Lopes, Manuel Sobrinho-Simões, Paula Soares  Journal of Investigative Dermatology  Volume 134, Issue 8, Pages 2251-2257 (August 2014) DOI: 10.1038/jid.2014.163 Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Kaplan–Meier curves for disease-free and overall survival of cutaneous melanoma patients. Kaplan–Meier curves demonstrating the correlation between telomerase (TERT) promoter mutations and disease-free (a) and overall (b) survival of cutaneous melanoma patients. Patients with TERT promoter mutations (solid line) display significantly (P=0.04) reduced disease-free and overall survival compared with patients without TERT mutations (dashed line). Journal of Investigative Dermatology 2014 134, 2251-2257DOI: (10.1038/jid.2014.163) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Telomerase expression in melanoma. Telomerase (TERT) expression in acral (a), lentigo maligna (b), nodular (c), and superficial spreading (d) melanoma subtypes. DAB. Scale bars=200 μm (a–d). Journal of Investigative Dermatology 2014 134, 2251-2257DOI: (10.1038/jid.2014.163) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions