Bringing IDH into the Fold Gelareh Zadeh, Kenneth Aldape  Cancer Cell  Volume 29, Issue 2, Pages 139-140 (February 2016) DOI: 10.1016/j.ccell.2016.01.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Showing the Relationship of IDH Mutation Status to Insulator Function in Glioma In IDH-wild-type glioma (top panel), the FIP1L1 enhancer activates FIP1L1 expression. PDGFRA expression is insulated from this effect (via CTCF insulator binding). In contrast, IDH mutant tumors (lower panel) show aberrant methylation, reducing the binding of the insulator and resulting in elevated expression of PDGFRA to promote gliomagenesis. Cancer Cell 2016 29, 139-140DOI: (10.1016/j.ccell.2016.01.010) Copyright © 2016 Elsevier Inc. Terms and Conditions