The enigma of IgE+ B-cell memory in human subjects

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Presentation transcript:

The enigma of IgE+ B-cell memory in human subjects Janet M. Davies, PhD, Thomas A. Platts-Mills, MD, PhD, Rob C. Aalberse, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 972-976 (April 2013) DOI: 10.1016/j.jaci.2012.12.1569 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Low-affinity IgE contributes to basophil activation. FcεRI-bound IgE with moderate to high affinity for allergen takes the first step in binding to allergen. Subsequent binding of IgE to allergen (Step 2) does not require high-affinity IgE binding.23 IgE of low affinity contributes to allergen cross-linking of FcεRI-bound IgE and activation of basophils or tissue mast cells in patients with allergic reactions. Journal of Allergy and Clinical Immunology 2013 131, 972-976DOI: (10.1016/j.jaci.2012.12.1569) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Models of development of IgE in human subjects. In an incompletely organized GC, such as might occur in the allergic type TH2 milieu, B cells directly switch to IgE. IgE+ switched B cells rapidly exit the GC and differentiate into PCs, which is incapable of expansion and further GC activity.11 Existence of circulating memory B (mem B) IgE+ cells is contentious (faded shading). IgE+ B cells have low surface expression of IgE6 and do not compete within a mature GC for antigen and survival signals from T follicular helper cells (IL-21). In a mature GC, B-cell precursors indirectly switch to IgE through allergen-specific, somatically mutated IgG4 memory B cells, giving rise to high-affinity allergen-driven IgE. Rare IgE+ memory B cells might exist in human subjects to provide a pool of B cells to sustain IgE memory through direct differentiation to PCs. The figure was adapted and developed from Aalberse and Platts-Mills.1 Journal of Allergy and Clinical Immunology 2013 131, 972-976DOI: (10.1016/j.jaci.2012.12.1569) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions