Are GTGs ABA's Biggest Fans?

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Are GTGs ABA's Biggest Fans? Alexander Christmann, Erwin Grill Cell Volume 136, Issue 1, Pages 21-23 (January 2009) DOI: 10.1016/j.cell.2008.12.033 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 GTG1 and GTG2 in Abscisic Acid Signaling (A) A pair of guard cells from a leaf stomatal pore. Osmoregulated swelling and shrinking of guard cells control stomatal aperture and gas exchange. The phytohormone abscisic acid (ABA) induces stomatal closure by mediating solute loss from guard cells. Photograph kindly provided by Dr. P. Walther. (B) Model of GTG action in the ABA-induced stomatal closure. Upon ABA binding, GTG1 and GTG2 activate anion efflux from guard cells via the slow-type anion channel SLAC1 and the rapid-type channel (R-type), which has not yet been molecularly identified. Depolarization of guard cells allows activation of a cation efflux via the guard cell outward-rectifying potassium channel (GORK), resulting in water loss, to induce stomatal closure. The ABA response is negatively regulated by the protein phosphatase ABI1, a key regulator of early steps in the ABA signal transduction. ABI1 also counteracts signaling by an unknown cytoplasmic ABA receptor R. The GTPase activity of GTGs is inhibited by the GTP-bound Gα subunit GPA1. The ATP-/GTP-binding region of GTG1 is in the proximity of the carboxy-terminal end and is marked in red, while the region with similarity to Ras GTPase-activating protein domain is highlighted in blue. Cell 2009 136, 21-23DOI: (10.1016/j.cell.2008.12.033) Copyright © 2009 Elsevier Inc. Terms and Conditions