Garlic extract increases non-clipped kidney tubular natriuresis and diuresis in the 2- kidney, 1-clip rat model: Significance in hypertension Khaled K.

Slides:

Advertisements

Similar presentations

Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes Khaled K. Al-Qattan, Mohamed H. Mansour,

Advertisements

Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease Yava L. Jones-Hall, Matthew B.

Poor glycemic control and decreased renal function are associated with increased intrarenal RAS activity in Type 2 diabetes mellitus S. Nakatani, E.

Volume 65, Issue 6, Pages (June 2004)

Antioxidant Treatment Prevents Renal Damage and Dysfunction and Reduces Arterial Pressure in Salt-Sensitive Hypertension by Niu Tian, Kristina D. Thrasher,

Contribution of nitric oxide synthase (NOS) in blood–brain barrier disruption during acute focal cerebral ischemia in normal rat Mohammad T. Mohammadi,

Volume 16, Issue 2, Pages (August 2009)

Volume 63, Issue 6, Pages (June 2003)

Efficacy and safety of dapagliflozin in patients with type 2 diabetes and concomitant heart failure Mikhail Kosiborod, Ingrid Gause-Nilsson, John Xu,

Plasma sodium and hypertension

Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats Mahmoud Hosseini, S. Mohammad.

Management of hypertension in patients with chronic kidney disease

Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome

Volume 25, Issue 4, Pages (December 2018)

Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes Khaled K. Al-Qattan, Mohamed H. Mansour,

Volume 25, Issue 2, Pages (June 2018)

Elevated cardiac 3-deoxyglucosone, a highly reactive intermediate in glycation reaction, in doxorubicin-induced cardiotoxicity in rats Tomoyuki Moriyama,

Effect of the two new calcium channel blockers mebudipine and dibudipine on vascular flow of isolated kidney of normal and diabetic rats Lili Sepehr-Ara,

Alligator pepper/Grain of Paradise (Aframomum melegueta) modulates Angiotensin-I converting enzyme activity, lipid profile and oxidative imbalances in.

Volume 65, Issue 6, Pages (June 2004)

Volume 18, Issue 2, Pages (April 2011)

Volume 63, Issue 6, Pages (June 2003)

Lunar biological effects and the magnetosphere

Volume 23, Issue 4, Pages (December 2016)

Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure Christos P. Carvounis, Sabeeha Nisar, Samerah Guro-Razuman

Volume 23, Issue 1, Pages (March 2016)

Volume 21, Issue 4, Pages (November 2014)

Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin Khaled K. Al-Qattan, Martha.

Volume 77, Issue 8, Pages (April 2010)

Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia A. Jimoh, Y. Tanko,

Volume 23, Issue 4, Pages (December 2016)

Volume 22, Issue 4, Pages (December 2015)

Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin- induced diabetic rats Ali M. Sharifi, Behnoush Zare, Morteza Keshavarz,

Cardiac and autonomic responses to change in posture or vitamin C supplementation in sickle cell anemia subjects S.I. Jaja, M.O. Kehinde, S.I. Ogungbemi

Volume 81, Issue 3, Pages (February 2012)

Volume 17, Issue 1, Pages (February 2010)

Volume 20, Issue 4, Pages (September 2013)

Volume 75, Issue 2, Pages (January 2009)

Volume 68, Issue 6, Pages (December 2005)

Volume 19, Issue 3, Pages (June 2012)

L-arginine supplementation lowers blood pressure, protein excretion and plasma lipid profile in experimental salt-induced hypertension in pregnancy: Relevance.

David A. Clark, Upender K. Munshi Pathophysiology

Volume 85, Issue 3, Pages (March 2014)

Peripheral brain-derived neurotrophic factor is reduced in stroke survivors with cognitive impairment Tasneem M. Hassan, Isyaku U. Yarube Pathophysiology

Volume 16, Issue 1, Pages 3-7 (June 2009)

Volume 18, Issue 2, Pages (April 2011)

Volume 65, Issue 2, Pages (February 2004)

Oral contraceptive administration aggravates nitric oxide synthesis inhibition-induced high blood pressure in female rats L.A. Olatunji, A.O. Soladoye

Skin cancer epidemic in a wireless world

Zhiyong Ming, Seppo Pietikainen, Osmo Hänninen Pathophysiology

Volume 84, Issue 5, Pages (November 2013)

Increasing incidence of brain tumours in sparsely populated areas

Kpop: A Python package for population genetics analysis

Β2 Adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats G.M.T. Hare, J.M.A. Worrall, A.J. Baker, E. Liu,

The effect of maintenance and reversal of DOCA-Salt hypertension on extravasation of macromolecules and serum nitric oxide concentration in male rats

Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats Quaisar Ali,

Volume 69, Issue 5, Pages (March 2006)

Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats L.A. Olatunji, A.O. Soladoye Pathophysiology

Renal phenotype of low kallikrein rats

Inhibition of pressure natriuresis in mice lacking the AT2 receptor

Dr Mahmood S. Mozaffari, Stephen W. Schaffer Kidney International

Effect of proteinuria and glomerular filtration rate on cardiovascular risk in essential hypertension Julian Segura, Carlos Campo, Luis M. Ruilope Kidney.

Salt sensitivity in genetically hypertensive rats of the Lyon strain

Role of neuropeptide Y in the development of two-kidney, one-clip renovascular hypertension in the rat Lynn H. Shin, MD, Peter S. Dovgan, MD, Timothy.

Renal blood flow in experimental septic acute renal failure

Effect of prenatal dexamethasone on rat renal development

Volume 61, Issue 1, Pages (January 2002)

Kidney and hypertension

Quantitative estimation of renal blood flow by power Doppler ultrasonography in renovascular hypertensive dogs Tetsumasa Miyajima, Hiroshi Yokoyama,

Temporal adaptation of tubuloglomerular feedback: Effects of COX-2

Presentation transcript:

Garlic extract increases non-clipped kidney tubular natriuresis and diuresis in the 2- kidney, 1-clip rat model: Significance in hypertension Khaled K. Al-Qattan, Martha Thomson, Muslim Ali Pathophysiology Volume 24, Issue 4, Pages 317-325 (December 2017) DOI: 10.1016/j.pathophys.2017.08.004 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the SBP in Nr and 2K-1Cr. The basal SBP in the 2K-1Cr was significantly higher than in the Nr. Furthermore, the SBP in either group of rats was not affect by RGAE within the first hour after 10min of administration. SBP: systolic blood pressure; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the HR in Nr and 2K-1Cr. The basal HR was significantly higher in the 2K-1Cr compared to the Nr. In addition, the HR in both groups of rats, although mildly however significantly, was less following the administration of RGAE. HR: heart rate; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-CC in Nr and 2K-1Cr. The basal level of LK-CC was significantly higher in the 2K-1Cr, however it was significantly elevated only in the Nr in response to the administration of RGAE. LK-CC: left kidney cortical circulation; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-GFR in Nr and 2K-1Cr. The basal LK-GFR was higher in the 2K-1Cr group and in response to the administration of RGAE increased only in the Nr. LK-GFR: left kidney glomerular filtration rate; Nr: Nr/BL: normal rat/basal level (before i.v. RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before i.v. RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect). Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 5 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-UV in Nr and 2K-1Cr. The administration of RGAE significantly increased the LK-UV in both groups of rats although the basal urine output was significantly higher in the 2K-1Cr. LK-UV: left kidney urine volume; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compare to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 6 Effect of i.v. RGAE (30mg/100g b.wt.) on the LK-U/Osmo in Nr and 2K-1Cr. The basal level of LK-U/Osm was significantly lower in the 2K-1Cr and the administration of RGAE significantly reduced the urine osmolarity in both groups of rats. LK-U/Osm: left kidney urine osmolarity; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 7 Effect of i.v. RGAE (30mg/100g b.wt.) on the P-Osmo in Nr and 2K-1Cr. The basal plasma osmolarity was similar in both groups of rats. Furthermore, it was not affect by the RGAE administration. P-Osmo: plasma osmolarity; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE). Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 8 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-ClNa in Nr and 2K-1Cr. Similar to the behavior of the urine output, the LK-ClNa was significantly higher in the 2K-1Cr and again the clearance of sodium significantly increased in both groups of rats in response to RGAE administration. LK-ClNa: left kidney sodium clearance; normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 9 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-FEH2O in Nr and 2K-1Cr. The LK-FEH2O behavior in both groups was similar to that for LK-UV. The fractional excretion of water was higher in the 2K-1Cr and again was significantly elevated in both groups of rats in response to RGAE administration. LK-FEH2O: left kidney fractional excretion of water; Nr; Nr/BL: normal rat/basal level (before RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect of RGAE); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect of RGAE); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 10 Effect of i.v. administration of RGAE (30mg/100g b.wt.) on the LK-FENa in Nr and 2K-1Cr. The LK-FENa showed a similar behavior to that of LK-FEH2O where it was significantly higher in the 2K-1C and also increased in both groups of rats in response to RGAE administration. LK-FENa: left kidney fractional excretion of sodium; Nr/BL: normal rat/basal level (before i.v. RGAE administration); Nr/RGAE: normal rat/raw garlic aqueous extract (effect); 2K-1Cr/BL: 2 kidney-1 clip rat/basal level (before i.v. RGAE administration); 2K-1Cr/RGAE: 2 kidney-1 clip rat/raw garlic aqueous extract (effect); a: significant compared to BL; b: significant compared to Nr/BL; c: significant compared to Nr/RGAE. Pathophysiology 2017 24, 317-325DOI: (10.1016/j.pathophys.2017.08.004) Copyright © 2017 Elsevier B.V. Terms and Conditions