A Breakdown in Cooperativity Leads to Cardiac Identity Crisis

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A Breakdown in Cooperativity Leads to Cardiac Identity Crisis Ana Vujic, Ahmed I. Mahmoud, Richard T. Lee Cell Volume 167, Issue 7, Pages 1674-1676 (December 2016) DOI: 10.1016/j.cell.2016.11.056 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Interaction between GATA4 and TBX5 in Cardiac Gene Regulation (A) WT cardiomyocyte transcriptional regulation is modulated by GATA4-TBX5 co-binding to MED1-bound cardiac super-enhancers activating key cardiac genes. Simultaneously, HDAC2 is recruited, resulting in a closed chromatin state at endothelial promoters. (B) The GATA4 G296S missense mutation suppresses the expression of cardiac specific genes by changing the proximity of TBX5 to GATA4. A failure to recruit HDAC2 with a euchromatin structure at endothelial promoters allows for mislocalization of TBX5 and expression of endothelial genes. Cell 2016 167, 1674-1676DOI: (10.1016/j.cell.2016.11.056) Copyright © 2016 Elsevier Inc. Terms and Conditions