Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 Päivi.

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Presentation transcript:

Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Renee Jaramillo, MStat, Agustin Calatroni, MA, MS, Charles H. Weir, MS, MPH, PhD, Michelle L. Sever, MPH, PhD, Jane A. Hoppin, ScD, Kathryn M. Rose, PhD, Andrew H. Liu, MD, Peter J. Gergen, MD, MPH, Herman E. Mitchell, PhD, Darryl C. Zeldin, MD Journal of Allergy and Clinical Immunology Volume 134, Issue 2, Pages 350-359 (August 2014) DOI: 10.1016/j.jaci.2013.12.1071 Copyright © 2014 Terms and Conditions

Fig 1 Prevalence of positive serum IgE test results and distributions of allergen-specific antibody concentrations in the US population. A and B, Subjects aged 6 years and older. C and D, Subjects aged 1 to 5 years. Box plots display minimum and maximum values and 25th, 50th, and 75th percentiles. The measuring range was 0.35 to 1000 kUA/L. LLOD, Lower limit of detection; ULOD, upper limit of detection. Journal of Allergy and Clinical Immunology 2014 134, 350-359DOI: (10.1016/j.jaci.2013.12.1071) Copyright © 2014 Terms and Conditions

Fig 2 Clustering of allergen-specific IgEs. The dendrogram (right) uses hierarchic clustering to group similar sIgEs based on the log-transformed correlation matrix (left). Hierarchic cluster analysis identified 7 IgE clusters: (1) plants (grass-, tree-, weed-, and peanut-specific IgEs); (2) dust mites (D farinae and D pteronyssinus); (3) pets (dog and cat); (4) cockroach and shrimp; (5) molds (Alternaria alternata and Aspergillus fumigatus); (6) foods (egg white and cow’s milk); and (7) rodents (mouse and rat). Journal of Allergy and Clinical Immunology 2014 134, 350-359DOI: (10.1016/j.jaci.2013.12.1071) Copyright © 2014 Terms and Conditions

Fig 3 Prevalence of positive serum IgE test results by age among the US population. Solid symbols represent statistically significant differences, whereas prevalences that are not statistically different are marked with open symbols. Red symbols indicate the subgroup of allergens measured in 1- to 5-year-old children. Journal of Allergy and Clinical Immunology 2014 134, 350-359DOI: (10.1016/j.jaci.2013.12.1071) Copyright © 2014 Terms and Conditions

Fig 4 Prevalence of positive serum IgE test results by demographic characteristics in the US population. A, Subjects aged 6 years and older. B, Subjects aged 1 to 5 years. Solid symbols represent statistically significant differences, whereas prevalences that are not statistically different are marked with open symbols. Journal of Allergy and Clinical Immunology 2014 134, 350-359DOI: (10.1016/j.jaci.2013.12.1071) Copyright © 2014 Terms and Conditions

Fig 5 Prevalence of positive serum IgE test results by census region in the US population. A, Subjects aged 6 years and older. B, Subjects aged 1 to 5 years. Journal of Allergy and Clinical Immunology 2014 134, 350-359DOI: (10.1016/j.jaci.2013.12.1071) Copyright © 2014 Terms and Conditions