Figure 1 Research advances in osteoarthritis management Figure 1 | Research advances in osteoarthritis management. A novel drug-delivery system can prolong the analgesic effect of intra-articular glucocorticoids for knee osteoarthritis (OA). Results of clinical trials shed light on the long-term effects of intra-articular glucocorticoids and on the therapeutic potential of a small-molecule inhibitor of the Wnt signalling pathway for OA. Fz, Frizzled; LRP, lipoprotein receptor-related protein. McAlindon, T. E. & Bannuru, R. R. (2018) Latest advances in the management of knee OA Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.219