Volume 13, Issue 12, Pages (December 2012)

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Volume 13, Issue 12, Pages 1242-1249 (December 2012) Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial Prof John C Mathers, PhD, Mohammad Movahedi, PhD, Prof Finlay Macrae, MD, Jukka-Pekka Mecklin, MD, Gabriela Moeslein, MD, Sylviane Olschwang, MD, Prof Diana Eccles, MD, Prof Gareth Evans, MD, Prof Eamonn R Maher, MD, Lucio Bertario, MD, Marie-Luise Bisgaard, MD, Prof Malcolm Dunlop, MD, Judy WC Ho, MD, Prof Shirley Hodgson, MD, Annika Lindblom, MD, Prof Jan Lubinski, MD, Prof Patrick J Morrison, MD, Victoria Murday, MD, Prof Raj Ramesar, PhD, Lucy Side, MD, Rodney J Scott, PhD, Huw JW Thomas, PhD, Hans Vasen, MD, Prof Anne-Marie Gerdes, MD, Gail Barker, Gillian Crawford, MSc, Faye Elliott, MSc, Kirsi Pylvanainen, CRA, Juul Wijnen, PhD, Prof Riccardo Fodde, PhD, Prof Henry Lynch, MD, D Timothy Bishop, PhD, Prof Sir John Burn, MD The Lancet Oncology Volume 13, Issue 12, Pages 1242-1249 (December 2012) DOI: 10.1016/S1470-2045(12)70475-8 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Study profile The Lancet Oncology 2012 13, 1242-1249DOI: (10.1016/S1470-2045(12)70475-8) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Time to first colorectal cancer in participants randomly assigned to resistant starch versus those assigned to resistant-starch placebo Kaplan-Meier analysis, adjusted for sex (A). Kaplan-Meier analysis restricted to participants who had taken the intervention for 2 years or more, adjusted for sex (B). Each point on the plot shows the estimated cumulative incidence by years of follow-up together with the corresponding 95% CI. CAPP=Colorectal Adenoma/carcinoma Prevention Programme. The Lancet Oncology 2012 13, 1242-1249DOI: (10.1016/S1470-2045(12)70475-8) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 3 Time to first Lynch syndrome cancer in participants randomly assigned to resistant starch versus those assigned to resistant-starch placebo Kaplan-Meier analysis was restricted to participants who had taken the intervention for 2 years or more and the analysis was adjusted for sex. Each point on the plot shows the estimated cumulative incidence by years of follow-up together with the corresponding 95% CI. CAPP=Colorectal Adenoma/carcinoma Prevention Programme. The Lancet Oncology 2012 13, 1242-1249DOI: (10.1016/S1470-2045(12)70475-8) Copyright © 2012 Elsevier Ltd Terms and Conditions