CNS Injury: IL-33 Sounds the Alarm

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Presentation transcript:

CNS Injury: IL-33 Sounds the Alarm Simmie L. Foster, Sébastien Talbot, Clifford J. Woolf Immunity Volume 42, Issue 3, Pages 403-405 (March 2015) DOI: 10.1016/j.immuni.2015.02.019 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Oligodendrocytes Sound the Alarm upon CNS Injury In a model based on Gadani et al., spinal cord contusion injury promotes IL-33 release from oligodendrocytes. Other as-yet-to-be identified factors are also released and increase astrocyte expression of St2 (IL-33R) and decrease its expression in microglia. Newly released IL-33 stimulates astrocytes to promote monocyte chemotaxis through the CCL2-CCR2 axis. Diverse factors, including IL-33, skew these invading macrophages to adopt a M2 polarized state that then promotes injury recovery. Immunity 2015 42, 403-405DOI: (10.1016/j.immuni.2015.02.019) Copyright © 2015 Elsevier Inc. Terms and Conditions