Wnt to Notch Relay Signaling Induces Definitive Hematopoiesis

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Wnt to Notch Relay Signaling Induces Definitive Hematopoiesis Dirk Loeffler, Konstantinos D. Kokkaliaris, Timm Schroeder Cell Stem Cell Volume 9, Issue 1, Pages 2-4 (July 2011) DOI: 10.1016/j.stem.2011.06.011 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Signaling Pathways Involved in Specification of Vertebrate Definitive Hematopoiesis Non-cell-autonomous signaling in somites via wnt16/Notch pathways is first required before the formation of the dorsal aorta (left). HSC specification is later induced by cell-autonomous signaling including HH/VEGF/Notch in the ventral wall of the dorsal aorta (right). S, somite; NT, neural tube; N, notochord; DA, dorsal aorta; CV, cardinal vein; HH, hedgehog; NL, Notch ligand. Cell Stem Cell 2011 9, 2-4DOI: (10.1016/j.stem.2011.06.011) Copyright © 2011 Elsevier Inc. Terms and Conditions