Sweet Talk: Regulating Glucose Metabolism in Toxoplasma

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Presentation transcript:

Sweet Talk: Regulating Glucose Metabolism in Toxoplasma Ann M. Guggisberg, Audrey R. Odom Cell Host & Microbe Volume 18, Issue 2, Pages 142-143 (August 2015) DOI: 10.1016/j.chom.2015.07.012 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of Metabolic Regulation by TgFBP2 TgFBP2 participates in gluconeogenesis (glucose synthesis), the reverse of glycolysis (glucose breakdown). TgFBP2 is co-expressed alongside glycolytic enzymes, such as phosphofructokinase (PFK), and is required for growth, even in glucose-rich conditions. This points to a novel role for TgFBP2 as a metabolic regulator, allowing the cell to “fine-tune” its metabolism and direct metabolic flux. Metabolic consequences of TgFBP2 knockdown include increased lactate production and a decrease in TCA cycle intermediates. Cell Host & Microbe 2015 18, 142-143DOI: (10.1016/j.chom.2015.07.012) Copyright © 2015 Elsevier Inc. Terms and Conditions