Structural Neurology: Are Seeds at the Root of Neuronal Degeneration? Peter T Lansbury  Neuron  Volume 19, Issue 6, Pages 1151-1154 (December 1997) DOI: 10.1016/S0896-6273(00)80406-7

Figure 1 Protein Concentration and the Duration of Supersaturation Both Affect the Process of Ordered Aggregation The process of ordered protein aggregation (e.g., amyloid formation and PrPSc formation) depends on protein concentration and the time during which supersaturation is maintained. This leads to a time-dependent phase diagram containing three regions. The black circle represents the in vivo conditions. If these conditions fall in the red zone, aggregation will occur and disease will result. If they fall in either of the two green zones, no aggregation will occur. This zone is likely to be experienced in “normal” metabolism (black circle). Several scenarios could trigger aggregation (a move of the black circle into the red zone). Neuron 1997 19, 1151-1154DOI: (10.1016/S0896-6273(00)80406-7)