Hopping between Differentiation States in Lung Adenocarcinoma

Slides:

Advertisements

Similar presentations

Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Silvia Di Agostino,

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells Roger R. Gomis, Claudio Alarcón, Cristina Nadal, Catherine.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity Cai-Hong.

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression Jason A. Reuter, Susana.

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model for Malignant Mesothelioma Johan Jongsma, Erwin van Montfort, Marc Vooijs, John Zevenhoven, Paul Krimpenfort, Martin van der.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

The Kinase-Independent, Second Life of CDK6 in Transcription

“Atypical” Regulation of Hedgehog-Dependent Cancers

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

Volume 1, Issue 1, Pages (June 2007)

Metastasis gets site specific

The LUNGe to Model Alveolar Lung Diseases in a Dish

Nicole R. Murray, Verline Justilien, Alan P. Fields Cancer Cell

The Ids Have It Cancer Cell

Mutant p53 gain of function: The NF-Y connection

Volume 9, Issue 6, Pages (June 2006)

Sox2: Masterminding the Root of Cancer

TCF-1 Flips the Switch on Eomes

A Mitochondrial Power Play in Lymphoma

Three Down and One To Go: Modeling Medulloblastoma Subgroups

Andrew G. Muntean, Jay L. Hess Cancer Cell

Volume 2, Issue 6, Pages (June 2008)

Cell signaling and cancer

MDS Is a Stem Cell Disorder After All

T.S. Karin Eisinger-Mathason, M. Celeste Simon Cancer Cell

Eun-Jung Jung, George A. Calin Cancer Cell

APLCC ORAL ABSTRACT SESSIONS - MONDAY, NOVEMBER 26

ABT-199: Taking Dead Aim at BCL-2

Wing Y. Chang, William L. Stanford Cell Stem Cell

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Volume 9, Issue 6, Pages (June 2006)

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

Plasticity of Adult Stem Cells

Learning the ABCs of Melanoma-Initiating Cells

Metabolic Networks of Longevity

MicroRNAs in Tfh Cells: Micromanaging Inflammaging

Heike Döppler, Peter Storz Cell Metabolism

Cancer Genomes Evolve by Pulverizing Single Chromosomes

Puma: Mauling the Intestinal Crypt

The Not-so-Skinny on Muscle Cancer

Phytochromes: Where to Start?

Frances Balkwill, Kellie A. Charles, Alberto Mantovani Cancer Cell

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization Tsukasa Shibue, Mary W.

Powering Reprogramming with Vitamin C

Bmi1 and Cell of Origin Determinants of Brain Tumor Phenotype

NO Signals from the Cancer Stem Cell Niche

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

Volume 10, Issue 3, Pages (September 2006)

Volume 23, Issue 6, Pages (June 2013)

All Roads Lead to the Ribosome

Learning the ABCs of Melanoma-Initiating Cells

There's a Time and a Place for MYCN

TCF-1 Flips the Switch on Eomes

Volume 17, Issue 2, Pages (February 2010)

Ibrutinib Treatment of CLL: The Cancer Fights Back

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

The Ups and Downs of Src Regulation: Tumor Suppression by Cbp

Presentation transcript:

Hopping between Differentiation States in Lung Adenocarcinoma Hideo Watanabe, Matthew Meyerson Cancer Cell Volume 23, Issue 6, Pages 707-709 (June 2013) DOI: 10.1016/j.ccr.2013.05.013 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Metastatic Potential Varies among Subtypes of Lung Cancer Defined by Transcriptional Regulation of Cell Lineages Transcriptional regulators active in different cell lineages are shaded in green (WNT/TCF), yellow (SOX2), orange (FOXA1), red (NKX2-1), and blue (GATA6/HOPX). Arrows indicate differentiation. Curved arrows indicate malignant transformation. Cancer Cell 2013 23, 707-709DOI: (10.1016/j.ccr.2013.05.013) Copyright © 2013 Elsevier Inc. Terms and Conditions