Yuqiu Jiang, Graham Casey, Ian C

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Presentation transcript:

Development of a Clinically Feasible Molecular Assay to Predict Recurrence of Stage II Colon Cancer Yuqiu Jiang, Graham Casey, Ian C. Lavery, Yi Zhang, Dmitri Talantov, Michelle Martin-McGreevy, Marek Skacel, Elena Manilich, Abhijit Mazumder, David Atkins, Conor P. Delaney, Yixin Wang The Journal of Molecular Diagnostics Volume 10, Issue 4, Pages 346-354 (July 2008) DOI: 10.2353/jmoldx.2008.080011 Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 ROC and Kaplan-Meier survival analysis of the prognostic signatures on 123 independent patients. A: The ROC curve of the 23-gene signature. B: Kaplan-Meier curve and log rank test of 123 frozen tumor samples using the 23-gene signature. The risk of recurrence for each patient was assessed based on the gene signature and the threshold was determined by the previous study.17 The high and low risk groups differ significantly (P = 0.045). C: The ROC curve of the 7-gene signature. D: Kaplan-Meier curve and log rank test of 123 frozen tumor samples using the 7-gene signature. The risk of recurrence for each patient was assessed based on the gene signature and the threshold was determined by the training set. The high and low risk groups differ significantly (P = 0.025). The Journal of Molecular Diagnostics 2008 10, 346-354DOI: (10.2353/jmoldx.2008.080011) Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 ROC and Kaplan-Meier survival analysis of the prognostic signatures on 110 independent patients. A: The ROC curve of the 7-gene signature. B: Kaplan-Meier curve and log rank test of 110 FPE tumor samples using the 7-gene signature. The risk of recurrence for each patient was assessed based on the gene signature and the threshold was determined by the training set. The high and low risk groups differ significantly (P < 0.0001). The Journal of Molecular Diagnostics 2008 10, 346-354DOI: (10.2353/jmoldx.2008.080011) Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions