$13.8 Billion Hip Fractures $8.68 billion (63.1%)

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$13.8 Billion Hip Fractures $8.68 billion (63.1%) Other Sites $5.08 billion (36.9%) Ray et al. JBMR 1997; 12(1):24-35 1/18/2019 OSTEOPOROSIS

$13.8 Billion Attributable to In-patient care (62.4%) $8.6 billion Nursing Home (28.2%) $3.9 billion Outpatient Services (9.4%) $1.3 billion Ray et al. JBMR 1997; 12(1):24-35

Comparative health care expenditures for osteoporosis, heart failure, and asthma >$10 Billion $7.5 Billion $6.2 Billion OSTEOPOROSIS CHF ASTHMA N Engl J Med 1/18/2019 OSTEOPOROSIS

Future Projections … it is estimated that only 9% of patients with osteoporosis are diagnosed and treated … 1/18/2019 OSTEOPOROSIS

… in 1999 Actonel & Fosamax had combined worldwide sales of $1.06 b Evista totaled $326.1 m Direct costs of … the market for osteoporosis treatment, excluding HRT, was $2.4 billion in the 12 months ending June 2001 1/18/2019 OSTEOPOROSIS

Future Projections $50 billion Direct costs of Osteoporosis by 2040 $50 billion 1/18/2019 OSTEOPOROSIS