Baby budgeting: oocyte cryopreservation in women delaying reproduction can reduce cost per live birth Kate Devine, M.D., Sunni L. Mumford, Ph.D., Kara.

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Presentation transcript:

Baby budgeting: oocyte cryopreservation in women delaying reproduction can reduce cost per live birth Kate Devine, M.D., Sunni L. Mumford, Ph.D., Kara N. Goldman, M.D., Brooke Hodes-Wertz, M.D., M.P.H., Sarah Druckenmiller, B.S., Anthony M. Propst, M.D., Nicole Noyes, M.D. Fertility and Sterility Volume 103, Issue 6, Pages 1446-1453.e2 (June 2015) DOI: 10.1016/j.fertnstert.2015.02.029 Copyright © 2015 Terms and Conditions

Figure 1 Schematic representation of treatment strategies analyzed in cost-effectiveness analysis. a Strategy 1: OC × 1.2 cycles (mean number required to obtain 16 meiosis II oocytes at age 35 years), attempt spontaneous conception for 6 months at age 40 years, and 2 oocyte thaw cycles using stored oocytes if no live birth. b Strategy 2: OC × 1.2 cycles, attempt spontaneous conception at age 40 years for 6 months, 2 fresh autologous assisted reproductive technology (ART) cycles if no live birth, 2 oocyte thaw cycles using stored oocytes if still no live birth. c Strategy 3: no OC at age 35 years, attempt spontaneous conception at age 40 years for 6 months, 2 fresh autologous ART cycles if no live birth. OC = oocyte cryopreservation. Fertility and Sterility 2015 103, 1446-1453.e2DOI: (10.1016/j.fertnstert.2015.02.029) Copyright © 2015 Terms and Conditions

Figure 2 Sensitivity analyses comparing cost-effectiveness between treatment strategies while varying individual model inputs. Each panel represents a separate sensitivity analysis, in which the model input named on the X-axis was varied, whereas all other model inputs were held constant. Cost per live birth is represented on the Y-axis such that lower points on each graph represent the more cost-effective strategy for the given model input. Model inputs varied in the sensitivity analyses included: (A) age at oocyte cryopreservation (OC), (B) probability of live birth at age 40 years from 6 months' attempts at spontaneous conception, (C) cost of OC, and (D) cost of an IVF cycle. In all panels, the blue line represents Strategy 1, the green line represents Strategy 2, and the red line represents Strategy 3. See Figure 1 and methods for a detailed description of each strategy. Fertility and Sterility 2015 103, 1446-1453.e2DOI: (10.1016/j.fertnstert.2015.02.029) Copyright © 2015 Terms and Conditions