Apoptosis, Up the Ante Cancer Cell

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Apoptosis, Up the Ante Cancer Cell Palaniraja Thandapani, Iannis Aifantis Cancer Cell Volume 32, Issue 4, Pages 402-403 (October 2017) DOI: 10.1016/j.ccell.2017.09.009 Copyright © 2017 Terms and Conditions

Figure 1 AML Combinatorial Therapy Using BAX Activators and BH3 Mimetics Overexpression of pro-survival BCL-2 proteins in cancers inhibits apoptosis by suppressing pro-apoptotic BAX/BAK. BH3 mimetics like venetoclax and navitoclax release BAX/BAK by neutralizing pro-survival BCL-2 members and sensitize cells to apoptosis. Direct BAX activators like BTSA1 can directly activate BAX and induce cell death synergistically with BH3 mimetics like venetoclax. Cancer Cell 2017 32, 402-403DOI: (10.1016/j.ccell.2017.09.009) Copyright © 2017 Terms and Conditions