The Reparative Function of Cardiomyocytes in the Infarcted Myocardium

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The Reparative Function of Cardiomyocytes in the Infarcted Myocardium Nikolaos G. Frangogiannis Cell Metabolism Volume 21, Issue 6, Pages 797-798 (June 2015) DOI: 10.1016/j.cmet.2015.05.015 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Cytokine-Stimulated Cardiomyocytes in the Infarct Border Zone Activate Anti-inflammatory and Reparative Cascades Lörchner et al. (2015) demonstrated that surviving cardiomyocytes (CM) in the infarct border zone (BZ) respond to stimulation with oncostatin-M (OSM), released by leukocytes, by secreting Reg3β. Release of Reg3β mediates recruitment of macrophages (Ma) that may phagocytose apoptotic neutrophils (N), activating anti-inflammatory and reparative responses (Mo, monocyte). Cell Metabolism 2015 21, 797-798DOI: (10.1016/j.cmet.2015.05.015) Copyright © 2015 Elsevier Inc. Terms and Conditions