Distinct mutations at the same positions of STAT3 cause either loss or gain of function Prabha Chandrasekaran, PhD, Ofer Zimmerman, MD, Michelle Paulson,

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Presentation transcript:

Distinct mutations at the same positions of STAT3 cause either loss or gain of function Prabha Chandrasekaran, PhD, Ofer Zimmerman, MD, Michelle Paulson, MD, Elizabeth P. Sampaio, MD, PhD, Alexandra F. Freeman, MD, Kathryn J. Sowerwine, MD, Darell Hurt, PhD, Julio C. Alcántara-Montiel, MD, PhD, Amy P. Hsu, BA, Steven M. Holland, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 4, Pages 1222-1224.e2 (October 2016) DOI: 10.1016/j.jaci.2016.05.007 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Functional characterization of STAT3 mutations: WT or mutant STAT3 allele transfected Cos-7 (A and B) or U3A (C) cells were assessed for pY(705)STAT3 by flow cytometry after stimulation with Oncostatin M or varying concentrations of IL-6. D, The electrostatic potential near the WT or mutated STAT3 residues and their DNA binding. Negative charge is shown in red, positive in blue. MFI, Mean fluorescent intensity; OSM, Oncostatin M; WT, wild-type. Journal of Allergy and Clinical Immunology 2016 138, 1222-1224.e2DOI: (10.1016/j.jaci.2016.05.007) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Previously reported STAT3 mutations by STAT3 domain. Hypomorphic DN mutations found in patients with HIES (Job's) are indicated in purple; hypermorphic GOF mutations found in patients with leukemia or lymphoma are indicated in green; hypermorphic GOF mutations found in patients with autoimmune disorders are indicated in orange. Journal of Allergy and Clinical Immunology 2016 138, 1222-1224.e2DOI: (10.1016/j.jaci.2016.05.007) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions