Unravelling Spinal Circuits of Pain and Mechanical Allodynia

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Unravelling Spinal Circuits of Pain and Mechanical Allodynia Vijayan Gangadharan, Rohini Kuner Neuron Volume 87, Issue 4, Pages 673-675 (August 2015) DOI: 10.1016/j.neuron.2015.08.013 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 The Conundrum of Allodynia Top: How do pathways mediating tactile sensation and pain interact to produce allodynia? Bottom: A model of circuits mediating mechanically evoked pain and mechanical allodynia, based on results reported in Peirs et al., 2015 and Duan et al., 2014. PN, projection neurons; V, vertical cells; VGLUT3, vesicular glutamate transporter type 3; SOM, somatostatin; EX, excitatory neuron; IN, inhibitory neuron; Dyn, dynorphin; PKCγ, protein kinase C γ; CR, calretinin. Neuron 2015 87, 673-675DOI: (10.1016/j.neuron.2015.08.013) Copyright © 2015 Elsevier Inc. Terms and Conditions