a b c d f e Proportion survival (%) Proportion survival (%)

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a b c d f e Proportion survival (%) Proportion survival (%) Simple HDK n=21 Proportion survival (%) Proportion survival (%) Trisomy 3 n=48 Proportion survival (%) 1 ASA n=30 Trisomy 5 n=48 2 ASA n=20 No trisomy 3 n=33 No trisomy 5 n=33 ≥3 ASA n=81 P=.0556 P=.0218 P= .0026 Months from diagnosis Months from diagnosis Months from diagnosis d f e Proportion survival (%) Proportion survival (%) Proportion survival (%) No monosomy 14 n=74 Trisomy 15 n=25 No monosomy 13 n=52 Monosomy 14 n=7 No trisomy 15 n=57 Monosomy 13 n=29 P=.0144 P=.0259 P=.0303 Months from diagnosis Months from diagnosis Months from diagnosis