K. Klemm Clinical Microbiology and Infection

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Laboratory diagnosis and biosafety issues of biological warfare agents

K. Kümmerer, A. Henninger Clinical Microbiology and Infection

Circulating levels of sTNFR and discrepancy between cytotoxicity and immunoreactivity of TNF-α in patients with visceral leishmaniasis I.M. Medeiros,

Approach to diagnosis of infective endocarditis

The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram- positive bacteria M.J. Rybak Clinical Microbiology and Infection

Herpes zoster in non-hospitalized children

K. Kümmerer, A. Henninger Clinical Microbiology and Infection

In vitro effects of cefotaxime and ceftriaxone on Salmonella typhi within human monocyte-derived macrophages B. Ekinci, A.Y. Coban, A. Birinci, B. Durupinar,

Virological tools to diagnose and monitor hepatitis C virus infection

Current patterns and evolution of antibiotic resistance among bacterial pathogens involved in acute otitis media Fernando Baquero, Rafael Cantón, Fernando.

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Non-antibiotic strategies for sepsis

P. Davey, C. Pagliari, A. Hayes Clinical Microbiology and Infection

How to evaluate and predict the epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach D. Guillemot Clinical Microbiology.

Trends in antibiotic prescribing in general internal medicine wards: antibiotic use and indication for prescription B. Maraha, M. Bonten, H. Fiolet,

Cutaneous sporotrichosis: the old iodide treatment remains effective

Vector control: a cornerstone in the malaria elimination campaign

C-3′Quaternary Ammonium Cephems, a New Wave of Cephalosporins

Training for the infectious diseases speciality in Norway

G. Höffken Clinical Microbiology and Infection

Retrospective study of CMV retinitis in patients with AIDS

B. Gordts Clinical Microbiology and Infection

Laboratory diagnosis and biosafety issues of biological warfare agents

Comparative in vitro activity of ertapenem against bacterial pathogens isolated from patients with lower respiratory tract infections P.S. Hicks, B.

Effects of gentamicin monotherapy for the initial treatment of community-onset complicated non-obstructive acute pyelonephritis due to Enterobacteriaceae.

A comparative study of the in vitro activity of meropenem and representatives of the major classes of broad-spectrum antibiotics J. Moira Greenhalgh,

Elements of design: the knowledge on which we build

In vitro selection of antibiotic resistance in Pseudomonas aeruginosa

Levofloxacin in the treatment of ventilator-associated pneumonia

R. Bitterman, M. Paul, D. Polak, Y. Geffen

Metagenomics and probiotics

Effect of antioxidants on the immune response of Helicobacter pylori

Laboratory diagnosis of Clostridium difficile disease

W.A. Craig Clinical Microbiology and Infection

Recent developments in staphylococcal scalded skin syndrome

S8 – S47 and O50 – O440 Clinical Microbiology and Infection

Pathogenesis of catheter-related infections: lessons for new designs

T.M. File Clinical Microbiology and Infection

Community-acquired pneumonia: epidemiologic and clinical consideration

Abstracts cont. Clinical Microbiology and Infection

Pandemic lineages of extraintestinal pathogenic Escherichia coli

Abstracts cont. Clinical Microbiology and Infection

Training in infectious diseases and tropical medicine in Britain

Fibronectin concentrations in catheter sepsis

Clinical infection services—the Leiden experience

Outpatient and home parenteral antibiotic therapy (OHPAT) in the UK: a consensus statement by a working party Dilip Nathwani, Christopher Conlon Clinical.

Clinical Microbiology and Infection

Clinical Microbiology and Infection

W. Eugene Sanders, Christine C. Sanders

Overview of cefixime use in community-acquired infections

A. Norberg, C.E. Nord, B. Evengård Clinical Microbiology and Infection

The atypical pneumonias: clinical diagnosis and importance

Facilitating learning and change in physicians: Implications for a system of continuing medical education in Europe Robert D. Fox Clinical Microbiology.

Abstracts Clinical Microbiology and Infection

New oral cephalosporins in pediatric community-acquired infections

In vitro activity of evernimicin and selected antibiotics against methicillin-resistant staphylococci: a 24-country study R. Goering, C.-E. Nord, R.

Carratalà J. Clinical Microbiology and Infection

In vitro activity of a new echinocandin, LY303366, and comparison with fluconazole, flucytosine and amphotericin B against Candida species† C.B. Moore,

B.A. Cunha Clinical Microbiology and Infection

N. Markeas, G. Stamos, I. Paraskakis, A. Giokas, G. Pistevos

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands J.W. Mouton, A.R. Jansz Clinical.

N. Markeas, G. Stamos, I. Paraskakis, A. Giokas, G. Pistevos

Impact of antibiotic restrictions: the patient's perspective

Decision-making in otitis media in children, Part I: epidemiologic data and definitions for a reliable cost-effectiveness analysis Bernard Grenier Clinical.

Outpatient and home parenteral antibiotic therapy (OHPAT) in the UK: a consensus statement by a working party Dilip Nathwani, Christopher Conlon Clinical.

Abstracts Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

The use of antibiotic-containing bead chains in the treatment of chronic bone infections K. Klemm Clinical Microbiology and Infection Volume 7, Issue 1, Pages 28-31 (January 2001) DOI: 10.1046/j.1469-0691.2001.00186.x Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Sequestration of infected devital bone fragments is the main feature in chronic osteomyelitis; radical surgery with removal of such sequestrum should proceed any antibiotic treatment – whether systemically or locally applied. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Release of gentamicin from gentamicin PMMA beads in vitro. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 Gentamicin PMMA chain and minichain for local antibiotic therapy by implantation in infected bone cavities, depending on the size of the defect. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 4 By implantation of a gentamicin PMMA chain into an infected bone cavity after sequestrectomy, local antibiotic therapy can be administered at local concentrations of gentamicin far above the MICs for most common pathogens in chronic osteomyelitis. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 5 Sequestrating osteomyelitis after plate osteosynthesis of a fracture in the subtrochanteric region; temporary implantation of a gentamicin PMMA chain following sequestrectomy. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 6 Temporary implantation of a gentamicin PMMA chain in the medullary canal of the tibia after removal of an infected interlocking nail. Clinical Microbiology and Infection 2001 7, 28-31DOI: (10.1046/j.1469-0691.2001.00186.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions