Age-related alterations in the genetics and genomics of the male germ line Amin S. Herati, M.D., Boryana H. Zhelyazkova, B.A., Peter R. Butler, B.A., Dolores J. Lamb, Ph.D. Fertility and Sterility Volume 107, Issue 2, Pages 319-323 (February 2017) DOI: 10.1016/j.fertnstert.2016.12.021 Copyright © 2016 Terms and Conditions
Figure 1 Reactive oxygen species generated from the mitochondrial electron transport chain (black arrow) damage DNA and mitochondrial DNA and disrupt telomerase activity, causing germ cell senescence. Fertility and Sterility 2017 107, 319-323DOI: (10.1016/j.fertnstert.2016.12.021) Copyright © 2016 Terms and Conditions
Figure 2 Development of genomic instability with aging. Fertility and Sterility 2017 107, 319-323DOI: (10.1016/j.fertnstert.2016.12.021) Copyright © 2016 Terms and Conditions