T-cell regulation in chronic paranasal sinus disease

Slides:



Advertisements
Similar presentations
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study  Aida Semic-Jusufagic, MD, Claus Bachert,
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis  Ana Rebane, PhD, Maya Zimmermann, PhD, Alar Aab,
Critical link between glycogen synthase kinase 3β and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps  Xingmei Wu, MD, Sihua.
Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A
Endotype-driven care pathways in patients with chronic rhinosinusitis
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic.
Obstructive sleep apnea syndrome and inflammation
Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance  Margot Berings, MD, Cagatay Karaaslan,
Sytze de Roock, PhD, Arie J
IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.
Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation 
The Editors' Choice Journal of Allergy and Clinical Immunology
T-cell regulation during viral and nonviral asthma exacerbations
Oral steroids and doxycycline: Two different approaches to treat nasal polyps  Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,
Regulation of TH17 cells in the mucosal surfaces
Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park,
Is 9 more than 2 also in allergic airway inflammation?
Suzana Radulovic, MD, Mikila R. Jacobson, PhD, Stephen R
Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid.
Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps  Atsushi Kato, PhD,
Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis  Philippe Gevaert, MD, PhD, Nicholas Van Bruaene, MD, Tom Cattaert,
Role of TWIK-related potassium channel-1 in chronic rhinosinusitis
Staphylococcus aureus enhances the tight junction barrier integrity in healthy nasal tissue, but not in nasal polyps  Can Altunbulakli, MSc, Rita Costa,
Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis  Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian.
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania  Xiangdong Wang, MD, PhD,
The Editors' Choice Journal of Allergy and Clinical Immunology
RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP  Koen Van Crombruggen, PhD, Gabriele Holtappels, Natalie De.
TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection  Mübeccel Akdis, MD, PhD, Oscar Palomares, PhD,
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases  Mübeccel Akdis, MD, PhD, Simone Burgler, PhD, Reto Crameri,
The future of allergy/immunology: Promising young investigators
The quest for autoreactive antibodies in nasal polyps
Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5.
David D. Tieu, MD, Anju T. Peters, MD, Roderick T
TGF-β signaling and collagen deposition in chronic rhinosinusitis
Activin A is an acute allergen-responsive cytokine and provides a link to TGF-β– mediated airway remodeling in asthma  Christian Karagiannidis, MD, Gabriele.
Zoulfia Allakhverdi, PhD, Michael R. Comeau, BSc, Dirk E
Claus Bachert, MD, PhD, Cezmi A. Akdis, MD 
Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: Potential role of histamine in airway remodeling  Steffen Kunzmann,
Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD 
IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,
Autophagy: Nobel Prize 2016 and allergy and asthma research
IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets  Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,
Allergic fungal rhinosinusitis—more than a fungal disease?
Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E
Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease  Nan Zhang, MD, PhD, Thibaut Van Zele, MD, PhD, Claudina.
Claus Bachert, MD, PhD, Luo Zhang, MD, Phillippe Gevaert, MD 
Biology of nasal polyposis
Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4  Michael B. Soyka, MD, Paulina Wawrzyniak,
Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy  Ulrich R. Müller, MD, Marek Jutel, MD,
Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps  Joke Patou, MD, Philippe Gevaert, MD, PhD, Thibaut.
Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M
Age-related differences in the pathogenesis of chronic rhinosinusitis
Macrolide antibiotics and asthma treatment
The Editors' Choice Journal of Allergy and Clinical Immunology
Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy.
Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania  Xiangdong Wang, MD, PhD,
An ex vivo model of severe asthma using reconstituted human bronchial epithelium  Delphine Gras, PhD, Arnaud Bourdin, MD, PhD, Isabelle Vachier, PhD, Laure.
Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis  Jennifer K. Mulligan, PhD, Whitney Nagel,
Dendritic cells in nasal mucosa of subjects with different allergic sensitizations  Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,
Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma  Philippe Gevaert, MD, PhD, Lien Calus, MD, Thibaut Van Zele,
Natural history of cow’s milk allergy
Der p 1–induced CD4+FOXP3+GATA3+ T cells have suppressive properties and contribute to the polarization of the TH2-associated response  Lieke Reubsaet,
Presentation transcript:

T-cell regulation in chronic paranasal sinus disease Nicholas Van Bruaene, MD, Claudina Angela Pérez-Novo, PhD, Tomasz M. Basinski, MSc, Thibaut Van Zele, MD, Gabriele Holtappels, Natalie De Ruyck, MSc, Carsten Schmidt-Weber, PhD, Cezmi Akdis, MD, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD, Philippe Gevaert, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 121, Issue 6, Pages 1435-1441.e3 (June 2008) DOI: 10.1016/j.jaci.2008.02.018 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Expression of FOXP3+ cells in nasal mucosa from healthy individuals (controls, CON) and subjects with CRSsNP or CRSwNP. Lack of staining is observed by blocking with FOXP3-immunizing peptide. Human tonsil sections served as a positive control with FOXP3+ cells located in the parafollicular cortex (T-cell zone). Original magnification was ×200 or ×400. For human tonsil magnification was ×100 or ×400. Representative slides are shown (n = 6 per group). Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 mRNA expression of transcription factors (FOXP3, T-bet, GATA-3) involved in naive T-cell differentiation in controls (CON), CRSwNP, and CRSsNP expressed as logarithm of normalized relative expression units/30 ng cDNA. Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 mRNA expression of key cytokines IFN-γ (TH1), IL-4, IL-5, IL-13 (TH2) (A), and iTreg-related TGF-β1 and IL-10 in controls (CON), CRSsNP, and CRSwNP (B), expressed as logarithm of normalized relative expression units/30 ng cDNA. For TGF-β1 and IFN-γ, additional protein measurements were performed, expressed as picograms per milliliter. Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions