T-cell regulation in chronic paranasal sinus disease

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Presentation transcript:

T-cell regulation in chronic paranasal sinus disease Nicholas Van Bruaene, MD, Claudina Angela Pérez-Novo, PhD, Tomasz M. Basinski, MSc, Thibaut Van Zele, MD, Gabriele Holtappels, Natalie De Ruyck, MSc, Carsten Schmidt-Weber, PhD, Cezmi Akdis, MD, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD, Philippe Gevaert, MD, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 6, Pages 1435-1441.e3 (June 2008) DOI: 10.1016/j.jaci.2008.02.018 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Expression of FOXP3+ cells in nasal mucosa from healthy individuals (controls, CON) and subjects with CRSsNP or CRSwNP. Lack of staining is observed by blocking with FOXP3-immunizing peptide. Human tonsil sections served as a positive control with FOXP3+ cells located in the parafollicular cortex (T-cell zone). Original magnification was ×200 or ×400. For human tonsil magnification was ×100 or ×400. Representative slides are shown (n = 6 per group). Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 mRNA expression of transcription factors (FOXP3, T-bet, GATA-3) involved in naive T-cell differentiation in controls (CON), CRSwNP, and CRSsNP expressed as logarithm of normalized relative expression units/30 ng cDNA. Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 mRNA expression of key cytokines IFN-γ (TH1), IL-4, IL-5, IL-13 (TH2) (A), and iTreg-related TGF-β1 and IL-10 in controls (CON), CRSsNP, and CRSwNP (B), expressed as logarithm of normalized relative expression units/30 ng cDNA. For TGF-β1 and IFN-γ, additional protein measurements were performed, expressed as picograms per milliliter. Journal of Allergy and Clinical Immunology 2008 121, 1435-1441.e3DOI: (10.1016/j.jaci.2008.02.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions