Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland

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Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland Thorgeir E. Thorgeirsson, Högni Oskarsson, Natasa Desnica, Jelena Pop Kostic, Jon G. Stefansson, Halldor Kolbeinsson, Eirikur Lindal, Nikolai Gagunashvili, Michael L. Frigge, Augustine Kong, Kari Stefansson, Jeffrey R. Gulcher The American Journal of Human Genetics Volume 72, Issue 5, Pages 1221-1230 (May 2003) DOI: 10.1086/375141 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Results of genomewide linkage analysis of 25 families (67 affected members), using a multiplexed framework set of 976 markers. The genotypes of 867 markers were used for analysis, resulting in an average intermarker distance of 4.4 cM. The multipoint allele-sharing LOD score is shown on the Y-axis, and the distance (in Kosambi cM) from the p-terminus of each chromosome is shown on the X-axis. The American Journal of Human Genetics 2003 72, 1221-1230DOI: (10.1086/375141) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Multipoint allele-sharing LOD scores for chromosome 9, using a higher-resolution map. With an average intermarker distance of 1.5 cM in the linked region, a multipoint LOD score of 4.18 was detected at marker D9S271 (105.6 cM). The multipoint allele-sharing LOD score is shown on the Y-axis, and the distance (in Kosambi cM) from the p-terminus is shown on the X-axis. The American Journal of Human Genetics 2003 72, 1221-1230DOI: (10.1086/375141) Copyright © 2003 The American Society of Human Genetics Terms and Conditions