Volume 147, Issue 5, Pages (November 2011)

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Volume 147, Issue 5, Pages 964-965 (November 2011) Anti-/Propsychotic Drug Signaling via Heteromeric GPCRs—A Balancing Act? Mari Kondo, Akira Sawa Cell Volume 147, Issue 5, Pages 964-965 (November 2011) DOI: 10.1016/j.cell.2011.11.012 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Comparison between Classic Neuroleptics and Newer Classes of Antipsychotics Clinical potency of classic neuroleptics has been understood on the basis of affinity to the dopamine D2 receptor (D2R) (upper panel). In contrast, Fribourg et al. propose that the intracellular Gi and Gq signaling balance (BI), downstream of a heteromeric complex composed of the serotonin 5-HT2A receptor (2AR) and metabotropic glutamate 2 receptor (mGluR2), provides a potential new metric for predicting the anti- or propsychotic activity of drugs targeting 2AR and mGluR2 (lower panel). Cell 2011 147, 964-965DOI: (10.1016/j.cell.2011.11.012) Copyright © 2011 Elsevier Inc. Terms and Conditions