Intestinal Flossing Keeps Pathogens at Bay

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Intestinal Flossing Keeps Pathogens at Bay Mirela Kuka, Matteo Iannacone Developmental Cell Volume 43, Issue 4, Pages 383-384 (November 2017) DOI: 10.1016/j.devcel.2017.11.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Intraepithelial Lymphocyte Dynamics The figure shows the behavior of IELs within an intestinal villus. Under homeostatic conditions, TCRγδ+ CD8aa+ lymphocytes (γδ IELs) monitor the intestinal epithelium by moving in the space between the epithelial layer and the basement membrane. When the IELs sense the presence of pathogens, via MyD88-dependent signaling in epithelial cells, they begin to exhibit “flossing” behavior—moving between epithelial cells—accompanied by metabolic reprogramming and an increase in the production of anti-microbial genes. Developmental Cell 2017 43, 383-384DOI: (10.1016/j.devcel.2017.11.006) Copyright © 2017 Elsevier Inc. Terms and Conditions