Diagnostic Value of Quantitative Hepatic Copper Determination in Patients With Wilson’s Disease  Peter Ferenci, Petra Steindl-Munda, Wolfgang Vogel, Wolfgang Jessner, Michael Gschwantler, Rudolf Stauber, Christian Datz, Franz Hackl, Fritz Wrba, Peter Bauer, Oskar Lorenz  Clinical Gastroenterology and Hepatology  Volume 3, Issue 8, Pages 811-818 (August 2005) DOI: 10.1016/S1542-3565(05)00181-3 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Regression of liver copper content on the age of patients at biopsy (r2 = 0.01; P = NS). Clinical Gastroenterology and Hepatology 2005 3, 811-818DOI: (10.1016/S1542-3565(05)00181-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Liver copper content (geometric mean and 95% CI) in control subjects, in patients with non-WD liver disease, and WD. P values were calculated by an unpaired, two-sided Student t test; all other patient groups were also different from patients with WD (P < .0001). normal, patients without histologic evidence of liver disease. Disease control subjects: CHC, chronic hepatitis C; various, patients with various non-WD chronic liver diseases. Clinical Gastroenterology and Hepatology 2005 3, 811-818DOI: (10.1016/S1542-3565(05)00181-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 ROC curve of hepatic copper content for diagnosis of WD (area under the curve, 0.988; 95% CI, 0.979–0.996). Diagnosis of WD was made by using the WD score developed by the Working Party at the 8th International Meeting on WD and Menkes disease 2001.9 Comparison of 114 WD patients with 219 disease control subjects. Clinical Gastroenterology and Hepatology 2005 3, 811-818DOI: (10.1016/S1542-3565(05)00181-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions