Regulating Sister Chromatid Separation by Separase Phosphorylation

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Regulating Sister Chromatid Separation by Separase Phosphorylation Koji Nagao, Mitsuhiro Yanagida Developmental Cell Volume 2, Issue 1, Pages 2-4 (January 2002) DOI: 10.1016/S1534-5807(01)00112-5

Figure 1 Mechanisms of Separase Regulation Stemmann et al. (2001) show that in mammalian cells the inactivation of separase is independently regulated by phosphorylation in addition to its association with the bound inhibitor securin. The mode of interaction between securin and separase in the complex is based on studies in fission yeast and fly. Developmental Cell 2002 2, 2-4DOI: (10.1016/S1534-5807(01)00112-5)