Charles J. Glueck, MD, Alan Brown, MD, Anne C. Goldberg, MD, James M

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Alirocumab in high-risk patients: Observations from the open-label expanded use program Charles J. Glueck, MD, Alan Brown, MD, Anne C. Goldberg, MD, James M. McKenney, PharmD, Louis Kantaros, MD, John Stewart, MSc, Joseph Elassal, MD, Andrew Koren, MD Journal of Clinical Lipidology Volume 12, Issue 3, Pages 662-668 (May 2018) DOI: 10.1016/j.jacl.2018.01.013 Copyright © 2018 National Lipid Association Terms and Conditions

Figure 1 Patient flow through the alirocumab expanded use program. AE, adverse event; Q2W, every 2 weeks. Journal of Clinical Lipidology 2018 12, 662-668DOI: (10.1016/j.jacl.2018.01.013) Copyright © 2018 National Lipid Association Terms and Conditions

Figure 2 Percent changes from baseline at week 24 in LDL-C and other lipid levels on alirocumab by (A) familial hypercholesterolemia (FH) status and (B) statin comedication status. N values represent the number of patients at week 24. The overall population pool included the patient who declined to take statin; this patient was not included in the “no statins” subgroup. CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; non-HDL-C, non–high-density lipoprotein cholesterol. Journal of Clinical Lipidology 2018 12, 662-668DOI: (10.1016/j.jacl.2018.01.013) Copyright © 2018 National Lipid Association Terms and Conditions